Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care

Description

this study is aiming at learning more about primary ciliary dyskinesia (PCD) and tests that are used to diagnose this condition. One purpose of this study is to measure the level of nitric oxide in the nasal passages and examine how often the results correlate with other tests currently done to make the diagnosis.

Conditions

Primary Ciliary Dyskinesia

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Study Overview

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Study Details

Study overview

this study is aiming at learning more about primary ciliary dyskinesia (PCD) and tests that are used to diagnose this condition. One purpose of this study is to measure the level of nitric oxide in the nasal passages and examine how often the results correlate with other tests currently done to make the diagnosis.

Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care

Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care

Condition
Primary Ciliary Dyskinesia
Intervention / Treatment

-

Contacts and Locations

Little Rock

Arkansas Children's Hospital, Little Rock, Arkansas, United States, 72202

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * • Individuals who are diagnosed with Primary Ciliary Dyskinesia OR
  • * Individuals undergoing PCD diagnostic testing (ciliary biopsy, PCD genetic testing) or concern based on clinical symptoms (at least two of the following):
  • * Neonatal respiratory distress
  • * Organ laterality defects
  • * Year-round cough starting in first year of life or bronchiectasis on chest CT
  • * Year-round nasal congestion starting in first year of life or pansinusitis
  • * Multiple ear infections in the first two years of life with sequelae (e.g. ear tubes, chronic effusion, abnormal audiological exam)
  • * Ability to provide consent for participation in study by the participants or guardian
  • * Ability to perform the test
  • * Age \>= 2 years of age
  • * • Individuals who are unable to understand the requirements of the study.
  • * Individuals (or guardians) who are unwilling to provide consent.
  • * Individuals who are unable to complete the testing
  • * Recent history of sinus surgery (within four weeks) or bloody nose (within one week) of testing (they can be included at a later date)
  • * Patients who are currently being treated (within one week) with antibiotics for sinusitis or respiratory symptoms (they can be included at a later date)
  • * Age \<2 years of age

Ages Eligible for Study

2 Years to 21 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Arkansas Children's Hospital Research Institute,

Study Record Dates

2025-06