RECRUITING

Ketorolac in Upper Extremity Tendinopathy and Arthropathy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Osteoarthritis (OA) and inflammatory conditions of the tendons and joints of the shoulder, elbow, hand, and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes corticosteroid and ketorolac injections which have been well investigated as a modality of pain control and improved function in large joint OA. However, fewer studies yielding mixed results on the duration of symptomatic relief exist for arthropathy and tendinopathy of these joints. The goal of this study is to evaluate the efficacy of ketorolac and triamcinolone injections for common shoulder, elbow, wrist, and hand tendinopathy or arthropathy. Participants will be blinded to the treatment received. The duration of an individual participant's participation in this study is 24 weeks. During this time period, patients will be asked to return to the clinic for an in-person follow-up 6 weeks after the injection with either ketorolac or triamcinolone) in order to assess participants' outcomes. All work related to this project will take place at the Emory Sports Medicine Complex, Emory Executive Park, Emory Musculoskeletal Institute, the Emory University Orthopaedic and Spine Hospital, and the Emory Saint Joseph's Hospital. This study will add to existing knowledge by providing further insight into how wrist arthropathy should be most optimally and conservatively managed.

Official Title

Single Blind RCT to Evaluate the Effect of Ketorolac in Upper Extremity Tendinopathy and Arthropathy

Quick Facts

Study Start:2023-01-31
Study Completion:2025-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05292339

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18 or older,
  2. * symptomatic tendinopathy or arthropathy of the shoulder, elbow, hand, or wrist who have not undergone prior surgical treatment for their condition.
  3. * Diagnoses may include trigger finger, De Quervain's tenosynovitis, radiocarpal osteoarthritis, first carpometacarpal (CMC) joint osteoarthritis, metacarpophalangeal joint osteoarthritis, or proximal interphalangeal joint osteoarthritis.
  1. * Patients under the age of 18,
  2. * Patients who have undergone prior triamcinolone or ketorolac injections within the past 6 months,
  3. * Patients who have undergone prior surgical treatment for their hand condition,
  4. * Patients with allergy or contraindication to triamcinolone or ketorolac injection,
  5. * Patients with an active infection at the treatment site \[active infection defined as cellulitis, purulence, fever, chills, or presence of elevated inflammatory markers, ie. white blood cells (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)\].

Contacts and Locations

Study Contact

Paul A. Ghareeb, MD
CONTACT
404-778-3350
paul.ghareeb@emory.edu

Principal Investigator

Paul A. Ghareeb, MD
PRINCIPAL_INVESTIGATOR
Emory University
Amanda L Dempsey
PRINCIPAL_INVESTIGATOR
Emory University

Study Locations (Sites)

Emory Saint Joseph's Hospital
Atlanta, Georgia, 30308
United States
Emory University Orthopaedic and Spine Center
Atlanta, Georgia, 30324
United States
12 Executive Park Drive
Atlanta, Georgia, 30329
United States
Emory University Orthopaedic and Spine Hospital
Atlanta, Georgia, 30329
United States

Collaborators and Investigators

Sponsor: Emory University

  • Paul A. Ghareeb, MD, PRINCIPAL_INVESTIGATOR, Emory University
  • Amanda L Dempsey, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-01-31
Study Completion Date2025-10

Study Record Updates

Study Start Date2023-01-31
Study Completion Date2025-10

Terms related to this study

Keywords Provided by Researchers

  • First Carpometacarpal Joint
  • Ketoralac
  • metacarpophalangeal joint osteoarthritis
  • trigger finger
  • De Quervain's tenosynovitis
  • radiocarpal osteoarthritis
  • Triamcinolone
  • Upper extremity

Additional Relevant MeSH Terms

  • Osteoarthritis
  • Tendinopathy
  • Arthropathy