COMPLETED

Carbon Dioxide (CO2) and Cognitive Impairment

Conditions

Healthy Carbon Dioxide Cognitive Impairment

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of the study is to better understand the biological mechanisms of carbon dioxide (CO2)-induced cognitive impairments.

Official Title

Carbon Dioxide (CO2): A Pilot Study of a Hypothesized Mechanism to Explain Cognitive Impairment

Quick Facts

Study Start:2022-07-14

Study Completion:2025-03-20

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT05292378

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 30 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* History of COVID-19 vaccination * Weigh at least 110 pounds	* Colorblindness * Inability to hear verbal instructions * Cardiovascular disease, including a history of stroke * Diabetes requiring the use of insulin * Pregnancy * Current asthma (an asthma attack within the past five years) * Medications for or history of anxiety disorder diagnosis or panic attacks * Medications which may affect cognition such as beta-blockers and CNS depressants * Respiratory symptoms in the previous four weeks * Use of sedating cold/allergy medications in the previous week * Use of marijuana in the previous week * Consumption of alcohol in the previous 24 hours * History of head trauma or neurosurgery or neurological disorder * Ferrous metal implanted in or on the body, electrical devices such as a pacemaker, nonremovable ferrous jewelry * Surgical pins or plates above the neck * History of eye injury involving metallic materials, shavings in eyes, or welding without a face mask * Lead or iron tatoos * Claustrophobia * Back problems that would prevent the subject from laying still comfortably for up to 90 minutes * Current or recent contact lens use

Inclusion Criteria

Exclusion Criteria

* History of COVID-19 vaccination
* Weigh at least 110 pounds

* Colorblindness
* Inability to hear verbal instructions
* Cardiovascular disease, including a history of stroke
* Diabetes requiring the use of insulin
* Pregnancy
* Current asthma (an asthma attack within the past five years)
* Medications for or history of anxiety disorder diagnosis or panic attacks
* Medications which may affect cognition such as beta-blockers and CNS depressants
* Respiratory symptoms in the previous four weeks
* Use of sedating cold/allergy medications in the previous week
* Use of marijuana in the previous week
* Consumption of alcohol in the previous 24 hours
* History of head trauma or neurosurgery or neurological disorder
* Ferrous metal implanted in or on the body, electrical devices such as a pacemaker, nonremovable ferrous jewelry
* Surgical pins or plates above the neck
* History of eye injury involving metallic materials, shavings in eyes, or welding without a face mask
* Lead or iron tatoos
* Claustrophobia
* Back problems that would prevent the subject from laying still comfortably for up to 90 minutes
* Current or recent contact lens use

Contacts and Locations

Principal Investigator

Howard Kipen, MD

PRINCIPAL_INVESTIGATOR

Professor

Study Locations (Sites)

Rutgers - EOHSI

Piscataway, New Jersey, 08854

United States

Collaborators and Investigators

Sponsor: Rutgers, The State University of New Jersey

Howard Kipen, MD, PRINCIPAL_INVESTIGATOR, Professor

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-07-14

Study Completion Date2025-03-20

Study Record Updates

Study Start Date2022-07-14

Study Completion Date2025-03-20

Terms related to this study

Keywords Provided by Researchers

Carbon Dioxide
Cognitive Impairment

Additional Relevant MeSH Terms

Healthy