This phase II trial tests whether NBT-NM108 works in reducing chemotherapy-induced diarrhea in patients with colon cancer that has spread to other places in the body (metastatic). Irinotecan is one of the most used medicine for colon cancer, but it leads to diarrhea in most patients receiving it and among some of them, severe diarrhea can occur. NBT-NM108 is a high dietary fiber formula that is developed based on research findings that have shown that high fiber diets can help maintain healthy bacteria in the gut and improve gut function. Giving NBT-NM108 to patients with colon cancer receiving chemotherapy may help relieve or lessen diarrhea symptoms and lead to improved tolerance of the chemotherapy drug, irinotecan.
Metastatic Colon Carcinoma, Stage IV Colon Cancer AJCC v8, Stage IVA Colon Cancer AJCC v8, Stage IVB Colon Cancer AJCC v8, Stage IVC Colon Cancer AJCC v8
This phase II trial tests whether NBT-NM108 works in reducing chemotherapy-induced diarrhea in patients with colon cancer that has spread to other places in the body (metastatic). Irinotecan is one of the most used medicine for colon cancer, but it leads to diarrhea in most patients receiving it and among some of them, severe diarrhea can occur. NBT-NM108 is a high dietary fiber formula that is developed based on research findings that have shown that high fiber diets can help maintain healthy bacteria in the gut and improve gut function. Giving NBT-NM108 to patients with colon cancer receiving chemotherapy may help relieve or lessen diarrhea symptoms and lead to improved tolerance of the chemotherapy drug, irinotecan.
Microbiotic Product to Promote Microbiome Health and Improve Chemotherapy Delivery
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Robert Wood Johnson University Hospital, Hamilton, Hamilton, New Jersey, United States, 08690
Monmouth Medical Center, Lakewood, New Jersey, United States, 08701
RWJBarnabas Health - Monmouth Medical Center Southern Campus, Lakewood, New Jersey, United States, 08701
Cooperman Barnabas Medical Center, Livingston, New Jersey, United States, 07039
Robert Wood Johnson University Hospital, New Brunswick, New Jersey, United States, 08901
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States, 08903
The Cancer Center, Newark, New Jersey, United States, 07103
Newark Beth Israel Medical Center, Newark, New Jersey, United States, 07112
Robert Wood Johnson University Hospital, Somerset, Somerville, New Jersey, United States, 08876
Community Medical Center, Toms River, New Jersey, United States, 08753
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to
ALL
No
Howard S. Hochster, MD,
Howard S Hochster, MD, PRINCIPAL_INVESTIGATOR, Rutgers University
2025-07-01