RECRUITING

The Effect of Bethanechol on Tracheobronchomalacia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The primary aim of this study is to determine if work of breathing estimated using swing Edi will be improved following initiation of bethanechol in infants with tracheobronchomalacia. The investigators hypothesize that work of breathing will be improved in infants with tracheobronchomalacia estimated by a 20% mean decrease in swing Edi following initiation of bethanechol.

Official Title

The Effect of Bethanechol on Work of Breathing and Expiratory Tracheal Collapse in Infants With Tracheobronchomalacia Measured by Electrical Activity of the Diaphragm and Bronchoscopy

Quick Facts

Study Start:2022-08-11
Study Completion:2024-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05299008

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Infants with a diagnosis of tracheobronchomalacia by dynamic computed tomography and showing \> 50% cross-sectional diameter collapse at 40 to 60 post menstrual age and for whom will be treatment with bethanechol in level IV center Neonatal Intensive Care Unit.
  1. * Infants with diagnosis of tracheobronchomalacia by dynamic computed tomography with \< 50% cross-sectional diameter collapse at 40 to 60 post menstrual age, or infants in which the medical team has not made the decision to start bethanechol.
  2. * Patients with fixed tracheomalacia or bronchomalacia due to external compression of airways.

Contacts and Locations

Study Contact

Charles P Pugh, MD
CONTACT
9013352402
cpugh2@uams.edu
David Matlock, MD
CONTACT
3184589097
dmatlock@uams.edu

Principal Investigator

Charles P Pugh, MD
PRINCIPAL_INVESTIGATOR
Arkansas Children's Hospital Research Institute

Study Locations (Sites)

Arkansas Children's Hospital
Little Rock, Arkansas, 72202
United States

Collaborators and Investigators

Sponsor: Arkansas Children's Hospital Research Institute

  • Charles P Pugh, MD, PRINCIPAL_INVESTIGATOR, Arkansas Children's Hospital Research Institute

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-08-11
Study Completion Date2024-06-30

Study Record Updates

Study Start Date2022-08-11
Study Completion Date2024-06-30

Terms related to this study

Keywords Provided by Researchers

  • bethanechol
  • swing Edi
  • Bronchoscopy

Additional Relevant MeSH Terms

  • Tracheobronchomalacia