Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations

Description

Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.

Conditions

Schizophrenia, Auditory Hallucination, Treatment-resistant Schizophrenia

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Study Overview

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Study Details

Study overview

Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.

Real-time fMRI Neurofeedback as a Tool to Mitigate Auditory Hallucinations in Patients With Schizophrenia - R33 Phase

Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations

Condition
Schizophrenia
Intervention / Treatment

-

Contacts and Locations

Brockton

Boston VA Healthcare System, Brockton, Brockton, Massachusetts, United States, 02301

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * patients diagnosed with SZ or schizoaffective disorder using DSM-5 criteria
  • * auditory hallucinations not responsive to pharmacology as determined by chart review and a clinical interview of SCID.
  • * neurologic illness
  • * major head trauma
  • * electroconvulsive therapy
  • * alcohol or drug dependence
  • * alcohol or drug abuse within the past five years
  • * verbal IQ below 70

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Boston VA Research Institute, Inc.,

margaret niznikiewicz, PRINCIPAL_INVESTIGATOR, Boston VA Research Institute, Inc.

Study Record Dates

2025-06-30