Symptomatic Carotid Outcomes Registry

Description

The purpose of this study is to build upon trials done over 30 years ago, which did not include statins, new antiplatelet agents, and newer antihypertensive medications. Since the landmark trials (NASCET, ECST), there have been new developments in medical stroke prevention, which creates a gap in knowledge. The aim of this study is to evaluate that clinical care with Intensive Medical Therapy (IMT) alone, the one year stroke rate in patients with symptomatic carotid stenosis and low risk clinical features will be \<5%.

Conditions

Carotid Stenosis, Ischemic Stroke, Transient Ischemic Attack

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Study Overview

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Study Details

Study overview

The purpose of this study is to build upon trials done over 30 years ago, which did not include statins, new antiplatelet agents, and newer antihypertensive medications. Since the landmark trials (NASCET, ECST), there have been new developments in medical stroke prevention, which creates a gap in knowledge. The aim of this study is to evaluate that clinical care with Intensive Medical Therapy (IMT) alone, the one year stroke rate in patients with symptomatic carotid stenosis and low risk clinical features will be \<5%.

Symptomatic Carotid Outcomes Registry With Multi-center Evaluation

Symptomatic Carotid Outcomes Registry

Condition
Carotid Stenosis
Intervention / Treatment

-

Contacts and Locations

Hartford

Hartford Hospital, Hartford, Connecticut, United States, 06102

Atlanta

Emory University Hospital, Atlanta, Georgia, United States, 30322

Chicago

Northwestern Memorial Hospital, Chicago, Illinois, United States, 60611

Chicago

Rush Medical Center, Chicago, Illinois, United States, 60612

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Baltimore

University of Maryland Medical Center, Baltimore, Maryland, United States, 21201

Springfield

Baystate Medical Center, Springfield, Massachusetts, United States, 01199

Worcester

University of Massachusetts Medical Center, Worcester, Massachusetts, United States, 01655

Rochester

University of Rochester, Rochester, New York, United States, 14642

Providence

Rhode Island Hospital, Providence, Rhode Island, United States, 02903

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥40 years plus stroke or TIA ipsilateral to 50-99% ICA stenosis
  • 1. Retinal ischemia only (amaurosis fugax, branch retinal artery occlusion (BRAO), central retinal artery occlusion (CRAO)
  • 2. Female sex
  • 3. Most recent stroke or TIA \>1 week ago
  • 1. Transcranial Doppler (TCD) study demonstrating lack of microembolic signals
  • 2. Cross-sectional MRI plaque imaging demonstrating absence of intraplaque hemorrhage
  • 3. For patients with TIA: brain MRI shows no DWI lesion

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Maryland, Baltimore,

Seemant Chaturvedi, MD, PRINCIPAL_INVESTIGATOR, School of Medicine, University of Maryland

Study Record Dates

2025-10