IV Iron Trial for Anemia Related to Uterine Bleeding in Female Patients Presenting to the Emergency Department

Eligibility Criteria

• * Sub-acute or chronic uterine blood loss;
• * Moderate to Severe Anemia, defined as Hgb less than or equal to 9.0 g/dl;
• * Iron deficiency: Serum ferritin less than or equal to 30 ng/mL;
• * Eligible for discharge from the ED following treatment;
• * Patient able to return for planned follow-up visits at 3 and 6 weeks;
• * Patient able to be reached by telephone;
• * Willing and able to provide consent for participation.
• * Patient requiring hospitalization for any reason;
• * Pregnant or nursing;
• * Incarcerated/Prisoner;
• * Weight \< 50 kg;
• * History of hypersensitivity reactions, as specified, known hypersensitivity to any formulation of parenteral iron;
• * History of any anaphylactic allergy;
• * Recent receipt of IV iron, erythropoiesis-stimulating agents;
• * Erythropoiesis-stimulating agent use within 8 weeks prior to ED visit;
• * Parenteral iron within 4 weeks prior to ED visit;
• * Scheduled/planned use of parenteral iron or ESA during study period;
• * Receipt of blood transfusion at index visit;
• * Planned elective major surgery during study period;
• * Other current or recent hematologic therapy, as specified;
• * Current or planned use of antithrombotic therapy (antiplatelet agents or anticoagulants) within study period (Non-aspirin NSAIDs are NOT a contraindication);
• * Known bleeding disorder platelets \< 100,000';
• * Other significant underlying comorbidity, as specified:
• * Active rheumatologic disease, or rheumatologist disease requiring treatment, such as rheumatoid arthritis, systemic lupus erythematosus, or mixed connective tissue disease;
• * Acute heart failure or NYHA II-IV chronic heart failure;
• * Inflammatory bowel disease;
• * Cirrhosis or Decompensated liver disease;
• * Chronic kidney disease, stage III or greater (eGFR \< 60);
• * Current Systemic Infection (e.g. pneumonia, pelvic inflammatory disease, pyelonephritis). \*Cystitis or cervicitis is NOT an exclusion
• * Any other medical or surgical condition that in the opinion of the treating physician may result in patient being unsuitable for trial participation