GAMBIT Task With PTSD and Healthy Control Participants

Eligibility Criteria

• * Male or female aged 18-55 years
• * Participants must be able to provide informed consent
• * Participants must have a level of understanding of the English language sufficient to agree to all tests and examinations required by the study and must be able to participate fully in the informed consent process
• * Must meet criteria for one of the following study groups:
• * PTSD Group:
• 1. Has been exposed to a Criterion A trauma of the civilian type (e.g., non-combat, threatened or actual interpersonal violence) or non-civilian
• 2. Must have a total score ≥ 25 on the CAPS-5 (past-month version) at the time of screening, indicating moderate PTSD symptom severity.
• * Healthy Control Group:
• * Current or lifetime history of schizophrenia or other psychotic disorder, bipolar disorder, obsessive-compulsive disorder (OCD), eating or feeding disorder, neurodevelopmental disorder, or neurocognitive disorder;
• * Any neuropsychiatric disorder that is judged to be the primary presenting problem, other than that which is specified as study group eligibility criteria;
• * Substance use disorder within the past 1 year;
• * Urine toxicology positive for illicit drugs or dis-allowed concomitant medications as per study protocol; intermittent cannabis use that does not meet criteria for a substance use disorder may be permitted under the protocol.
• * Suicidal ideation or risk of self-harm that is judged by the PI to be clinically significant and to warrant intervention
• * Concurrent treatment with opioid medication, or with long-acting or daytime short-acting benzodiazepines within two weeks of study start
• * Current cognitive impairment, as defined by a score \<23 on the Montreal Cognitive Assessment (MoCA)
• * Estimated IQ \<80
• * Currently receiving evidence-based psychotherapy for PTSD (e.g., prolonged exposure, cognitive processing therapy).