Sitting Interruption and Whole-body Cardiovascular Health

Description

There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke. However, the public currently has no clear guidance on how to limit or interrupt their sedentary behaviors. This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.

Conditions

Sedentary Behavior, Sedentary Time

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Study Overview

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Study Details

Study overview

There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke. However, the public currently has no clear guidance on how to limit or interrupt their sedentary behaviors. This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.

Sitting Interruption and Whole-body Cardiovascular Health: Linking Physiological Responses to Risk Behaviors

Sitting Interruption and Whole-body Cardiovascular Health

Condition
Sedentary Behavior
Intervention / Treatment

-

Contacts and Locations

Chapel Hill

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States, 27599

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aged between 36-55 years
  • * Insufficiently active: self-reported exercise \<90 minutes per week for the past 3 months
  • * Sedentary: self-reported sitting \>8 hours per day
  • * Self-reported ability to walk 4 blocks and climb 2 flights of stairs
  • * Possession of cellular phone able to receive text messages
  • * Use of assisted-walking devices
  • * Comorbid condition that would limit the ability to reduce sedentary behavior (e.g., musculoskeletal condition, current chemotherapy)
  • * Plans for major surgery within next 3 months
  • * Recent history (\<1 year) of ischemic heart disease, chronic heart failure, stroke, or chronic kidney disease
  • * Recent (\< 1 year) or planned bariatric surgery
  • * Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg
  • * Current or recent (within last 6 months) pregnancy; current or recent (within last 3 months) breastfeeding
  • * Morbidly obesity (BMI \>40 kg/m\^2) or underweight (BMI \<18.5 kg/m\^2)
  • * Use of anti-hypertensive drugs
  • * Use of glucose-controlling medication
  • * Heavy alcohol consumption (\>15 drinks per week)

Ages Eligible for Study

36 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of North Carolina, Chapel Hill,

Lee Stoner, PhD, PRINCIPAL_INVESTIGATOR, University of North Carolina, Chapel Hill

Study Record Dates

2026-02-28