RECRUITING

Sitting Interruption and Whole-body Cardiovascular Health

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke. However, the public currently has no clear guidance on how to limit or interrupt their sedentary behaviors. This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.

Official Title

Sitting Interruption and Whole-body Cardiovascular Health: Linking Physiological Responses to Risk Behaviors

Quick Facts

Study Start:2022-08-15
Study Completion:2026-02-28
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05316571

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:36 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Aged between 36-55 years
  2. * Insufficiently active: self-reported exercise \<90 minutes per week for the past 3 months
  3. * Sedentary: self-reported sitting \>8 hours per day
  4. * Self-reported ability to walk 4 blocks and climb 2 flights of stairs
  5. * Possession of cellular phone able to receive text messages
  1. * Use of assisted-walking devices
  2. * Comorbid condition that would limit the ability to reduce sedentary behavior (e.g., musculoskeletal condition, current chemotherapy)
  3. * Plans for major surgery within next 3 months
  4. * Recent history (\<1 year) of ischemic heart disease, chronic heart failure, stroke, or chronic kidney disease
  5. * Recent (\< 1 year) or planned bariatric surgery
  6. * Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg
  7. * Current or recent (within last 6 months) pregnancy; current or recent (within last 3 months) breastfeeding
  8. * Morbidly obesity (BMI \>40 kg/m\^2) or underweight (BMI \<18.5 kg/m\^2)
  9. * Use of anti-hypertensive drugs
  10. * Use of glucose-controlling medication
  11. * Heavy alcohol consumption (\>15 drinks per week)

Contacts and Locations

Study Contact

Simon Higgins, PhD
CONTACT
(706) 461-6776
higginss@unc.edu

Principal Investigator

Lee Stoner, PhD
PRINCIPAL_INVESTIGATOR
University of North Carolina, Chapel Hill

Study Locations (Sites)

University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599
United States

Collaborators and Investigators

Sponsor: University of North Carolina, Chapel Hill

  • Lee Stoner, PhD, PRINCIPAL_INVESTIGATOR, University of North Carolina, Chapel Hill

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-08-15
Study Completion Date2026-02-28

Study Record Updates

Study Start Date2022-08-15
Study Completion Date2026-02-28

Terms related to this study

Keywords Provided by Researchers

  • Sedentary Behavior
  • Interruption
  • Sitting
  • Cardiovascular
  • Arterial Stiffness
  • Pulse Wave Velocity

Additional Relevant MeSH Terms

  • Sedentary Behavior
  • Sedentary Time