RECRUITING

Wrist Extensor MEP Up-conditioning for Individuals With Incomplete Spinal Cord Injury

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to examine the relationship between common clinical assessments and measurements of the function of brain-spinal cord-muscle connections, and to examine the effects of training a brain-spinal cord-muscle response in individuals with incomplete spinal cord injury. A transcranial magnetic stimulator (TMS) is used for examining brain-to-muscle pathways. This stimulator produces a magnetic field for a very short period of time and indirectly stimulates brain cells with little or no discomfort. The target muscle is the wrist extensor (extensor carpi radialis) muscle that bends the wrist back. It is hypothesized that training the wrist extensor muscle response to transcranial magnetic stimulation will increase the strength of the brain-to-muscle pathway, which will improve the ability to move the arm. It is hoped that the results of this training study will help in developing therapy strategies for individuals, promoting better understanding of clinical assessments, and understanding treatments that aim to improve function recovery in people with spinal cord injury (SCI). This study requires 30 visits, and each visit will last approximately 1.5 hours.

Official Title

Can Increasing Motor Evoked Potential Size Improve Upper Extremity Motor Function in Individuals With Incomplete Spinal Cord Injury?

Quick Facts

Study Start:2021-10-12
Study Completion:2025-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05321017

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. a history of injury to spinal cord at or above C6
  2. 2. neurologically stable (\>6 mo post SCI)
  3. 3. medical clearance to participate
  4. 4. weak wrist extension at least unilaterally
  5. 5. expectation that current medication will be maintained without change for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted. In participants with bilateral wrist extension weakness, the more severely impaired arm is studied.
  1. 1. motoneuron injury
  2. 2. medically unstable condition
  3. 3. cognitive impairment
  4. 4. a history of epileptic seizures
  5. 5. metal implants in the cranium
  6. 6. implanted biomedical device in or above the chest (e.g., a cardiac pacemaker, cochlear implant)
  7. 7. no measurable MEP elicited in the ECR
  8. 8. unable to produce any voluntary ECR EMG activity
  9. 9. extensive use of functional electrical stimulation to the arm on a daily basis
  10. 10. pregnancy (due to changes in posture and potential medical instability).

Contacts and Locations

Study Contact

Blair Dellenbach, MSOT
CONTACT
843-792-6313
stecb@musc.edu

Principal Investigator

Blair Dellenbach, MSOT
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Blair Dellenbach, MSOT, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-10-12
Study Completion Date2025-06-30

Study Record Updates

Study Start Date2021-10-12
Study Completion Date2025-06-30

Terms related to this study

Additional Relevant MeSH Terms

  • Spinal Cord Injuries
  • Quadriplegia