COMPLETED

Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

When time allows, administration of mifepristone prior to second trimester induction of labor decreases total labor time. However, in the setting of many pregnancy complications, decreasing time from diagnosis of nonviable pregnancy to delivery is of utmost importance to decrease risk of maternal complications. Previous data has shown that total abortion time is longer in the group receiving mifepristone owing to the delay between mifepristone administration and initiation of misoprostol induction of labor. Thus, the investigators aim to investigate whether simultaneous mifepristone and misoprostol has benefits over misoprostol alone when labor induction of a nonviable second trimester cannot be delayed.

Official Title

Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial

Quick Facts

Study Start:2022-07-01
Study Completion:2025-07-14
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05322252

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18 years or older
  2. * 14 and 28 weeks' gestation
  3. * Singleton gestation
  4. * Nonviable fetus (i.e. fetal demise or previable gestational age/weight or lethal fetal anomaly)
  5. * Requires induction of labor
  6. * If fetal cardiac motion, abortion being performed for medical emergency per MO laws and consents completed
  1. * Contraindication to mifepristone
  2. * Plan for surgical evacuation of uterus
  3. * Contraindication to vaginal delivery
  4. * Plan to initiate induction with any medication or device except misoprostol
  5. * Declines participation

Contacts and Locations

Study Locations (Sites)

Barnes-Jewish Hospital
Saint Louis, Missouri, 63110
United States

Collaborators and Investigators

Sponsor: Washington University School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-07-01
Study Completion Date2025-07-14

Study Record Updates

Study Start Date2022-07-01
Study Completion Date2025-07-14

Terms related to this study

Additional Relevant MeSH Terms

  • Abortion, Second Trimester
  • PPROM
  • Rupture, Spontaneous
  • Fetal Demise
  • Fetal Death
  • Fetal Demise From Miscarriage
  • Fetal Death Before 22 Weeks With Retention of Dead Fetus
  • Pregnancy Loss
  • Pregnancy Complications