Functional Outcomes From Diets in Multiple Sclerosis

Description

The purpose of this study is to test the effects of two dietary interventions, glycemic load and calorie restriction, on physical function, cognition, pain, fatigue, mood, and anxiety in adults with multiple sclerosis (MS). The investigators will also explore the how the diet interventions impact inflammation, immunity, and metabolic biomarkers.

Conditions

Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis

Talk to us

Study Overview

On this page

Study Details

Study overview

The purpose of this study is to test the effects of two dietary interventions, glycemic load and calorie restriction, on physical function, cognition, pain, fatigue, mood, and anxiety in adults with multiple sclerosis (MS). The investigators will also explore the how the diet interventions impact inflammation, immunity, and metabolic biomarkers.

The Impact of Diet Quality and Calorie Restriction on Physical Function and Patient Reported Outcomes in Multiple Sclerosis

Functional Outcomes From Diets in Multiple Sclerosis

Condition
Relapsing Remitting Multiple Sclerosis
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35294

Saint Louis

Washington University, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosed with RRMS or SPMS
  • * BMI 25-50 kg/m2 (overweight/obese)
  • * EDSS ≤6.5 (able to walk 100m with or without assistance)
  • * If on disease-modifying treatment (DMT), stable for 6 months
  • * If not on DMT, no DMT in previous 6 months
  • * No expected change to DMT in next 34 weeks
  • * Responsible for food preparation or have input into food preparation
  • * MS relapse in previous 30 days
  • * Unable to walk 25 feet with or without assistive device
  • * Pregnant or breastfeeding
  • * Current use of insulin or sulfonylurea agents
  • * Score indicating low cognitive functioning on the Telephone Interview for Cognitive Status (TICS-m) assessment
  • * Actively engaged in a weight loss program or unwilling to follow assigned dietary pattern
  • * Unable to receive, store, or prepare food according to diet plan
  • * Medical contraindication to either treatment or control diet (including severe allergies that cannot be accommodated within either group)

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Alabama at Birmingham,

Brooks Wingo, PhD, PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

2026-01-31