Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * willing and able to give written informed consent
- * men or women,18-65 years of age
- * primary diagnosis of DSM (Diagnostic and Statistical Manual of Mental Disorders)-V MDD, current, as diagnosed by the SCID-I (Structured Clinical Interview for DSM Disorders)
- * score of ≥20 on the Beck Depression Inventory, which will include patients characterized as having "moderate/severe" (20-28) or "very-severe" (29-63) depressive symptoms
- * off all antidepressant therapy for at least 8 weeks prior to the baseline visit
- * willing and able to give written informed consent
- * men or women, 18-65 years of age
- * history of any bipolar disorder or psychotic disorder
- * active psychotic symptoms of any type
- * substance abuse/dependence within 6 months of study entry (as determined by SCID)
- * unstable cardiovascular, endocrinologic, hematologic, hepatic, renal, or neurologic disease (as determined by physical examination and laboratory testing), including upper respiratory disease or asthma, glaucoma or porphyria.
- * active suicidal ideation as determined by a score ≥3 on the Columbia Suicide Severity Rating Scale (C-SSR)
- * pregnancy or lactation
- * use of glucocorticoids at any time during the study
- * Raynaud's disease that may interfere with the cold-pressor
- * contraindications for MRI
- * MMSE (Mini-Mental State Exam) score \<28
- * elevated blood pressure prior to infusion (systolic \> 160 or diastolic \>100)
- * history of treatment resistance as determined by ATRQ (Antidepressant Treatment Response Questionnaire)
- * prior adverse reaction to ketamine
- * use of antipsychotic medications
- * use of greater than 2mg daily of lorazepam or similar benzodiazipine
- * evidence of any psychiatric disorder with exception of specific phobia, and no history of any psychiatric disorder except mild past substance use disorder as diagnosed by the SCID-I
- * history of any substance abuse within the last 6 months
- * use of any recreational drugs as confirmed by urine drug screen at the time of scanning
- * pregnancy or lactation
- * use of glucocorticoids at any time during the study
- * Raynaud's disease that may interfere with the cold-pressor
- * contraindications for MRI
- * MMSE score \<28
Ages Eligible for Study
18 Years to 65 Years
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
Yes