Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

Description

Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental impairments (NDI) at significant rates, disproportionate to their term peers. Early detection and intervention are critical to mitigate the impact of these impairments. Mechanisms leading from premature birth to these undesirable outcomes remain unclear, and accurate prognostic measures are lacking. This study wants to learn if these problems are related to certain patterns of breathing that babies had while they were in the NICU.

Conditions

Premature Birth, Asthma in Children, Sleep-Disordered Breathing, Neurodevelopmental Disorders

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Study Overview

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Study Details

Study overview

Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental impairments (NDI) at significant rates, disproportionate to their term peers. Early detection and intervention are critical to mitigate the impact of these impairments. Mechanisms leading from premature birth to these undesirable outcomes remain unclear, and accurate prognostic measures are lacking. This study wants to learn if these problems are related to certain patterns of breathing that babies had while they were in the NICU.

Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

Condition
Premature Birth
Intervention / Treatment

-

Contacts and Locations

Chicago

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States, 60611

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Enrolled in any Institutional Review Board (IRB) protocol of the Pre-Vent Study that had signed consent, or in any IRB protocol of the Pre-Vent Study that authorized re-contact for future research
  • * Born \<29 weeks gestational age
  • * Age at enrollment less than 7 years old
  • * Subject was withdrawn from the Pre-Vent study after signing Pre-Vent consent form, for any reason
  • * Subject had no physiological data recorded as part of Pre-Vent
  • * Lack of regulatory approval from local IRB or Department of Children and Family Services (DCFS) to recontact subjects
  • * Adopted by non-consenting family
  • * Parent refused further contact, prior to approach for Post-Vent
  • * Infant enrolled in Pre-Vent at Washington University St Louis, which is not a Post-Vent participating site.

Ages Eligible for Study

30 Weeks to 83 Months

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Ann & Robert H Lurie Children's Hospital of Chicago,

Debra Weese-Mayer, MD, PRINCIPAL_INVESTIGATOR, Ann & Robert H Lurie Children's Hospital of Chicago

Anna Maria Hibbs, MD, PRINCIPAL_INVESTIGATOR, Case Western Reserve University

Ambalavanan Namasivayam, MD, PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Nelson Claure, MSc, PhD, PRINCIPAL_INVESTIGATOR, University of Miami

Randall Moorman, MD, PRINCIPAL_INVESTIGATOR, University of Virginia

Study Record Dates

2026-06-30