Trans Auricular Vagus Nerve Stimulation (taVNS) and Robotic Training for Paralyzed Arm After Stroke

Description

To determine whether treatment with transauricular vagus nerve stimulation (taVNS) during the training of an affected upper limb of a patient with chronic stroke on a robotic motor task alters the motor impairment.

Conditions

Stroke, Hemiparesis

Study Overview

Study Details

Study overview

To determine whether treatment with transauricular vagus nerve stimulation (taVNS) during the training of an affected upper limb of a patient with chronic stroke on a robotic motor task alters the motor impairment.

Evaluating the Use of Trans Auricular Vagus Nerve Stimulation (taVNS) and Robotic Training to Improve Upper Limb Motor Recovery After Stroke

Trans Auricular Vagus Nerve Stimulation (taVNS) and Robotic Training for Paralyzed Arm After Stroke

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Manhasset

Feinstein Institutes at Northwell Health, Manhasset, New York, United States, 11030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * In receipt of full vaccination status and no recent upper respiratory symptoms and no loss of taste or olfaction.
  • * Individuals between 18 and 85 years of age
  • * First single focal unilateral supratentorial ischemic stroke with diagnosis verified by brain imaging (MRI or CT scans) that occurred at least 6 months prior
  • * Cognitive function sufficient to understand the experiments and follow instructions (per interview with Speech Pathologist or PI)
  • * Fugl-Meyer assessment 12 to 44 out of 66 (neither hemiplegic nor fully recovered motor function in the muscles of the shoulder, elbow, and wrist).
  • * Recent fever or upper respiratory symptoms.
  • * Botox treatment within 3 months of enrollment
  • * Fixed contraction deformity in the affected limb
  • * Complete and total flaccid paralysis of all shoulder and elbow motor performance
  • * Prior injury to the vagus nerve
  • * Severe dysphagia
  • * Introduction of any new rehabilitation interventions during study
  • * Individuals with scar tissue, broken skin, or irremovable metal piercings that may interfere with the stimulation or the stimulation device
  • * Highly conductive metal in any part of the body, including metal injury to the eye; this will be reviewed on a case by case basis for PI to make a determination
  • * Pregnant or plan on becoming pregnant or breastfeeding during the study period
  • * Significant arrhythmias, including but not limited to, atrial fibrillation, atrial flutter, sick sinus syndrome, and A-V blocks (enrollment to be determined by PI review)
  • * Presence of an electrically, magnetically or mechanically activated implant (including cardiac pacemaker), an intracerebral vascular clip, or any other electrically sensitive support system; Loop recorders will be reviewed on a case by case basis by PI and the treating Cardiologist to make a determination

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Northwell Health,

Bruce T Volpe, MD, PRINCIPAL_INVESTIGATOR, Feinstein Center for Molecular Medicine

Timir Datta Chaudhuri, PhD, STUDY_DIRECTOR, Feinstein Center for Bioelectronic Medicine

Study Record Dates

2025-04-18