Retinal Blood Flow and Autoregulation

Description

The purpose of this study is to establish autoregulation of retinal blood flow in arterioles and capillaries as a biomarker for early primary open angle glaucoma.

Conditions

Glaucoma

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Study Overview

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Study Details

Study overview

The purpose of this study is to establish autoregulation of retinal blood flow in arterioles and capillaries as a biomarker for early primary open angle glaucoma.

Direct Measures of Retinal Blood Flow and Autoregulation as Robust Biomarkers for Early Glaucoma

Retinal Blood Flow and Autoregulation

Condition
Glaucoma
Intervention / Treatment

-

Contacts and Locations

Baltimore

University of Maryland Faculty Physicians, Inc, Baltimore, Maryland, United States, 21201

Baltimore

University of Maryland Medical Center, Baltimore, Maryland, United States, 21201

Baltimore

University of Maryland, Baltimore, Baltimore, Maryland, United States, 21201

Silver Spring

Food and Drug Administration (FDA), Silver Spring, Maryland, United States, 20903

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. age over 18 years
  • 2. open angle in gonioscopy (grade 3 or 4 in Shaffer classification)
  • 3. refractive error within the range of +3.00 to -8.00 diopters (4) best-corrected visual acuity 20/25 or better (5) Individuals recruited will be in one of the 3 groups:
  • 1. corneal abnormalities or other conditions preventing reliable applanation tonometry
  • 2. retinal disease affecting retinal nerve fiber layer thickness such as vitreomacular traction as determined by a glaucoma specialist
  • 3. secondary glaucoma
  • 4. history of prior ocular surgery other than uncomplicated cataract surgery or laser trabeculoplasty
  • 5. inability to safely be off of glaucoma medications for 4 weeks
  • 6. inability to obtain OCT angiography data due to excessive eye motion or inability to fixate
  • 7. unreliable visual fields
  • 8. any history of smoking in the past 6 months
  • 9. cataract greater than lens opacity classification system (LOCS) II Grade≥2
  • 10. diagnosis of diabetes, hypertension, or other known vascular disorder such as vasculitis

Ages Eligible for Study

18 Years to 88 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Maryland, Baltimore,

Study Record Dates

2026-09