Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age

Eligibility Criteria

• * English-speaking
• * Pregnant
• * Live, singleton gestation
• * Patient able to provide informed consent
• * Gestational age between 18 weeks and 0 days and 22 weeks and 6 days at the time of -membrane rupture
• * Diagnosis of preterm, prelabor rupture of membranes by clinical exam findings of either 1) visualization of amniotic fluid passing from the cervical canal and/or pooling in the vagina via sterile speculum examination, 2) a basic pH (i.e., positive nitrazine) test of vaginal fluid, 3) arborization (i.e., ferning) of dried vaginal fluid identified via microscopic examination, and/or 4) an amniotic fluid index (AFI) of less than 4cm
• * Gestational dating performed or confirmed by ultrasound at ≥ 18 weeks and 0 days gestational age
• * Patient desires pregnancy interruption or induction of labor
• * Known major fetal anomaly or aneuploidy
• * Amniocentesis ≤ 7 days of diagnosis of rupture of membranes
• * Cervical cerclage placement ≤ 7 days of diagnosis of rupture of membranes
• * Known drug allergy or significant adverse reactions to macrolide or penicillin antibiotics
• * Current antibiotic use at the time of membrane rupture diagnosis
• * Vaginal bleeding at the time of membrane rupture diagnosis or within first 24 hours from diagnosis
• * Febrile at the time of membrane rupture diagnosis (i.e., temperature ≥ 38 degrees Celsius) and/or within first 24 hours of diagnosis
• * Active preterm labor at the time of membrane rupture diagnosis (i.e., consistent contraction pattern associated with cervical change) and/or within first 24 hours of diagnosis
• * Cervical dilation of ≥ 4 cm
• * Prolapse of fetal parts beyond the level of the internal cervical os
• * Declination to complete full, 7-day outpatient monitoring prior to hospital re-admission should rupture occur during the 22nd week of gestation