A Diagnostic for the Early Detection of Bladder Cancer

Description

To improve upon the non-invasive detection of bladder cancer by further validating a multiplex ELISA assay directed at a bladder cancer-associated diagnostic signature in voided urine samples of patients with a high risk of developing bladder cancer.

Conditions

Bladder Cancer

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Study Overview

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Study Details

Study overview

To improve upon the non-invasive detection of bladder cancer by further validating a multiplex ELISA assay directed at a bladder cancer-associated diagnostic signature in voided urine samples of patients with a high risk of developing bladder cancer.

A Novel Multiplex Immunoassay for the Early Detection of Bladder Cancer

A Diagnostic for the Early Detection of Bladder Cancer

Condition
Bladder Cancer
Intervention / Treatment

-

Contacts and Locations

Long Beach

Long Beach VA Healthcare System, Long Beach, California, United States, 90712

Los Angeles

Cedars-Sinai Medical Center, Los Angeles, California, United States, 90048

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age 50 years or older
  • 2. \>20 pack year history of tobacco exposure
  • 3. Free of any malignancy except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years. Patients with localized prostate cancer who are being followed by an active surveillance program are also eligible.
  • 4. Scheduled to be evaluated in the Pulmonary Rehab Clinic or Lung Cancer Screening Clinic
  • 5. Willing and able to give written informed consent
  • 6. Willing to provide voided urine sample
  • 7. Be able and willing to complete semi-annual research clinic visits for 4 years
  • 1. History of hematuria (microscopic or gross) within 2 years of signing consent.
  • 2. Previous history of bladder cancer
  • 3. A known active urinary tract infection or urinary retention
  • 4. An active stone disease (renal or bladder) or renal insufficiency (creatinine \>2.0 mg/dL) - Serum creatinine value can be up to 2 years before consent, otherwise repeat.
  • 5. An ureteral stents, nephrostomy tubes or bowel interposition
  • 6. A recent genitourinary instrumentation (within 7 days prior to collection of voided urine sample)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Cedars-Sinai Medical Center,

Hideki Furuya, PRINCIPAL_INVESTIGATOR, Cedars-Sinai Medical Center

Study Record Dates

2026-12-30