Exercise Training and Fat Metabolism in Postmenopausal Women

Description

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

Conditions

Postmenopausal Symptoms, Obesity, Prediabetic State

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Study Overview

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Study Details

Study overview

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

Resistance Training Modulation of Fat Metabolism in Obese Postmenopausal Women

Exercise Training and Fat Metabolism in Postmenopausal Women

Condition
Postmenopausal Symptoms
Intervention / Treatment

-

Contacts and Locations

Tallahassee

Florida State University, Tallahassee, Florida, United States, 32306

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Women
  • * Postmenopausal (50-70 yrs.)
  • * Obese (BMI 30-39.9 kg/m2)
  • * Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
  • * Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
  • * Non-smokers
  • * No hormone replacement therapy for at least the past two years.
  • * Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week)
  • * Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
  • * Type 1 or type 2 diabetes
  • * Medical problems in which exercise is contraindicated, such as chronic infections
  • * History of, or currently presentation with, cancer, cardiovascular or respiratory disease
  • * Uncontrolled thyroid dysfunction, liver or renal dysfunction
  • * Taking any medication affecting lipid metabolism
  • * Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
  • * Smokers and those with diagnosed eating disorders

Ages Eligible for Study

50 Years to 70 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Florida State University,

Robert C Hickner, PhD, PRINCIPAL_INVESTIGATOR, Florida State University

Michael J Ormsbee, PhD, PRINCIPAL_INVESTIGATOR, Florida State University

Mostafa M Ali, PhD, STUDY_DIRECTOR, Florida State University

Study Record Dates

2026-12