RECRUITING

Exercise Training and Fat Metabolism in Postmenopausal Women

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

Official Title

Resistance Training Modulation of Fat Metabolism in Obese Postmenopausal Women

Quick Facts

Study Start:2022-05-20
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05351476

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 70 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Women
  2. * Postmenopausal (50-70 yrs.)
  3. * Obese (BMI 30-39.9 kg/m2)
  4. * Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
  5. * Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
  6. * Non-smokers
  7. * No hormone replacement therapy for at least the past two years.
  1. * Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week)
  2. * Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
  3. * Type 1 or type 2 diabetes
  4. * Medical problems in which exercise is contraindicated, such as chronic infections
  5. * History of, or currently presentation with, cancer, cardiovascular or respiratory disease
  6. * Uncontrolled thyroid dysfunction, liver or renal dysfunction
  7. * Taking any medication affecting lipid metabolism
  8. * Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
  9. * Smokers and those with diagnosed eating disorders

Contacts and Locations

Study Contact

Robert C Hickner, PhD
CONTACT
850-644-1375
rhickner@fsu.edu
Michael J Ormsbee, PhD
CONTACT
850-644-2194
mormsbee@fsu.edu

Principal Investigator

Robert C Hickner, PhD
PRINCIPAL_INVESTIGATOR
Florida State University
Michael J Ormsbee, PhD
PRINCIPAL_INVESTIGATOR
Florida State University
Mostafa M Ali, PhD
STUDY_DIRECTOR
Florida State University

Study Locations (Sites)

Florida State University
Tallahassee, Florida, 32306
United States

Collaborators and Investigators

Sponsor: Florida State University

  • Robert C Hickner, PhD, PRINCIPAL_INVESTIGATOR, Florida State University
  • Michael J Ormsbee, PhD, PRINCIPAL_INVESTIGATOR, Florida State University
  • Mostafa M Ali, PhD, STUDY_DIRECTOR, Florida State University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-05-20
Study Completion Date2026-12

Study Record Updates

Study Start Date2022-05-20
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • Resistance Exercise
  • Fat Metabolism
  • Postmenopause

Additional Relevant MeSH Terms

  • Postmenopausal Symptoms
  • Obesity
  • Prediabetic State