Psilocybin Therapy for Chronic Low Back Pain

Description

This study evaluates whether psilocybin therapy helps patients cope with chronic low back pain more effectively. Patients may be recruited at Stanford and University of California San Francisco (UCSF), study procedures will occur at UCSF. Each participant will receive a dose of psilocybin with possibly one or more other drugs. Participants will undergo two preparation sessions, a dosing session, three integration sessions to discuss their psilocybin experience, and several follow up sessions.

Conditions

Chronic Low-back Pain

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Study Overview

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Study Details

Study overview

This study evaluates whether psilocybin therapy helps patients cope with chronic low back pain more effectively. Patients may be recruited at Stanford and University of California San Francisco (UCSF), study procedures will occur at UCSF. Each participant will receive a dose of psilocybin with possibly one or more other drugs. Participants will undergo two preparation sessions, a dosing session, three integration sessions to discuss their psilocybin experience, and several follow up sessions.

A Double-blind, Randomized Trial Examining the Preliminary Efficacy of Psilocybin Therapy for People With Chronic Low Back Pain

Psilocybin Therapy for Chronic Low Back Pain

Condition
Chronic Low-back Pain
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California San Francisco, San Francisco, California, United States, 94107

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 25 to 70 years old
  • * Comfortable speaking and writing in English
  • * Diagnosed with chronic low back pain
  • * Able to attend all in-person visits at UCSF as well as virtual visits
  • * Has tried at least two previous medications/ procedures and physical therapy trials for low back pain
  • * Chronic low back pain that is attributed to malignancy, subacute or acute fracture or infection
  • * Low back pain with radiation below the knee
  • * Low back pain with neurologic signs present
  • * Regular use of medications that may have problematic interactions with psilocybin, including but not limited to dopamine agonists, MAO inhibitors, antipsychotics, and stimulants
  • * A health condition that makes study unsafe or unfeasible, determined by study physicians

Ages Eligible for Study

25 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Joshua Woolley, MD/PhD,

Joshua Woolley, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2024-12