Chronotherapy in Children With Chronic Kidney Disease

Description

This is a pilot, crossover trial in which the investigator will determine if retiming of one anti-hypertensive medication from morning to evening can effectuate normal blood pressure dipping patterns in children and adolescents with chronic kidney disease.

Conditions

Chronic Kidney Diseases, Hypertension

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Study Overview

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Study Details

Study overview

This is a pilot, crossover trial in which the investigator will determine if retiming of one anti-hypertensive medication from morning to evening can effectuate normal blood pressure dipping patterns in children and adolescents with chronic kidney disease.

Investigating if Nocturnal Blood Pressure Patterns Are Modifiable in Children With Chronic Kidney Disease

Chronotherapy in Children With Chronic Kidney Disease

Condition
Chronic Kidney Diseases
Intervention / Treatment

-

Contacts and Locations

New Haven

Yale New Haven Children's Hospital/Yale New Haven Health, New Haven, Connecticut, United States, 06520

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or female child/adolescent up to 18 years of age with CKD
  • * estimated glomerular filtration rate (eGFR) of 30 to 90 ml/min/1.73 m2
  • * diagnosed with hypertension and on a stable dose of anti-hypertensive medication(s) for at least 3 months
  • * Non-dipping identified on ABPM
  • * history of organ transplantation, oncological disease, or dialysis
  • * inability to complete 24-hour ABPM or 24-hour urine collection
  • * Children less than 6 years of age will be excluded, as they often are unable to complete a successful ABPM study (≥ 40 readings, with 1 reading per hour of sleep)
  • * Currently on diuretic medications.

Ages Eligible for Study

6 Years to 18 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Yale University,

Christine Bakhoum, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2026-02