WITHDRAWN

Chronotherapy in Children With Chronic Kidney Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a pilot, crossover trial in which the investigator will determine if retiming of one anti-hypertensive medication from morning to evening can effectuate normal blood pressure dipping patterns in children and adolescents with chronic kidney disease.

Official Title

Investigating if Nocturnal Blood Pressure Patterns Are Modifiable in Children With Chronic Kidney Disease

Quick Facts

Study Start:2025-04
Study Completion:2026-02
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:WITHDRAWN

Study ID

NCT05353335

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:6 Years to 18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male or female child/adolescent up to 18 years of age with CKD
  2. * estimated glomerular filtration rate (eGFR) of 30 to 90 ml/min/1.73 m2
  3. * diagnosed with hypertension and on a stable dose of anti-hypertensive medication(s) for at least 3 months
  4. * Non-dipping identified on ABPM
  1. * history of organ transplantation, oncological disease, or dialysis
  2. * inability to complete 24-hour ABPM or 24-hour urine collection
  3. * Children less than 6 years of age will be excluded, as they often are unable to complete a successful ABPM study (≥ 40 readings, with 1 reading per hour of sleep)
  4. * Currently on diuretic medications.

Contacts and Locations

Principal Investigator

Christine Bakhoum
PRINCIPAL_INVESTIGATOR
Yale University

Study Locations (Sites)

Yale New Haven Children's Hospital/Yale New Haven Health
New Haven, Connecticut, 06520
United States

Collaborators and Investigators

Sponsor: Yale University

  • Christine Bakhoum, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04
Study Completion Date2026-02

Study Record Updates

Study Start Date2025-04
Study Completion Date2026-02

Terms related to this study

Additional Relevant MeSH Terms

  • Chronic Kidney Diseases
  • Hypertension