Collaborative Care in Posttraumatic Epilepsy

Description

The purpose of this research is to evaluate a 6 month change in quality of life in subjects who receive collaborative care calls compared to those subjects who receive usual neurology care. This is a 2-site trial comparing a 24 week neurology-based collaborative care program to usual neurology care among a total of 60 adults with post-traumatic epilepsy.

Conditions

Epilepsy, Post-Traumatic

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Study Overview

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Study Details

Study overview

The purpose of this research is to evaluate a 6 month change in quality of life in subjects who receive collaborative care calls compared to those subjects who receive usual neurology care. This is a 2-site trial comparing a 24 week neurology-based collaborative care program to usual neurology care among a total of 60 adults with post-traumatic epilepsy.

Collaborative Care for Anxiety and Depression in Posttraumatic Epilepsy

Collaborative Care in Posttraumatic Epilepsy

Condition
Epilepsy, Post-Traumatic
Intervention / Treatment

-

Contacts and Locations

Winston-Salem

Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina, United States, 27157

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Provision of signed and dated informed consent form
  • * Stated willingness to comply with all study procedures
  • * Diagnosis of post-traumatic epilepsy, defined by the following:
  • 1. Epilepsy diagnosis based on neurology clinician impression of diagnosis or electroencephalogram (EEG) findings (EEG findings: presence of interictal epileptiform discharges on EEG or ictal EEG recording of seizure definitively documenting epilepsy diagnosis)
  • 2. History of at least mild traumatic brain injury based on the MIRECC (Mental Illness Research, Education, and Clinical Center) TBI (Traumatic Brain Injury) screening instrument or verified TBI history based on MIRECC research database
  • 3. TBI pre-dated onset of epilepsy (NINDS post-traumatic epilepsy screening form)
  • * Anxiety or depression symptoms--Generalized Anxiety Disorder scale (GAD-7) ≥8 or Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) \>13
  • * Receiving clinical neurological care at one of the study sites
  • * Active ongoing treatment by a psychiatrist without the potential to benefit from additional collaborative care for anxiety or depression in the judgement of the investigators
  • * Active suicidal ideation
  • * History of past suicide attempt
  • * Unstable drug or alcohol abuse
  • * Unstable or progressive comorbid medical condition
  • * Current participation in another treatment or intervention study
  • * Cognitive limitations precluding completion of anxiety and depression self-report instruments on paper, electronically, or by interview.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Wake Forest University Health Sciences,

Heidi M. Munger Clary, MD, MPH, PRINCIPAL_INVESTIGATOR, Atrium Health Wake Forest Baptist

Study Record Dates

2025-07