COMPLETED

Remote Ischemic Conditioning, Bimanual Skill Learning, and Corticospinal Excitability

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Unilateral cerebral palsy (UCP) is a leading cause of childhood disability. An early brain injury impairs the upper extremity function, bimanual coordination, and impacts the child's independence. The existing therapeutic interventions have higher training doses and modest effect sizes. Thus, there is a critical need to find an effective priming agent to enhance bimanual skill learning in children with UCP. This study aims to determine the effects of a novel priming agent, remote ischemic conditioning (RIC), when paired with intensive bimanual skill training to enhance bimanual skill learning and to augment skill dependent plasticity in children with UCP.

Official Title

Effects of Remote Ischemic Conditioning on Bimanual Skill Learning, Bimanual Coordination, and Corticospinal Excitability in Children With Unilateral Cerebral Palsy

Quick Facts

Study Start:2021-12-18
Study Completion:2025-05-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05355883

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:6 Years to 16 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * Manual Ability Classification System (MACS) levels I-III
  2. * Ability to complete a stack of 3 cups in 2 minutes
  3. * Mainstream in school and has sufficient cognition to follow the experiment instructions
  1. * Children with other developmental disabilities such as autism, developmental coordination disorders, etc.
  2. * Children with absent active motor threshold
  3. * Children with cognitive deficits or communication problem
  4. * Children with known cardiorespiratory and vascular dysfunctions
  5. * Children with metabolic disorders, neoplasm, hydrocephalus
  6. * Children who are receiving other adjunct therapies such as rTMS and tDCS
  7. * Children with seizures and on anti-seizure medications
  8. * Children with metal implants and incompatible medical devices for MRI scans

Contacts and Locations

Principal Investigator

Swati Surkar
PRINCIPAL_INVESTIGATOR
East Carolina University

Study Locations (Sites)

Dept. of Physical Therapy, East Carolina University
Greenville, North Carolina, 27834
United States

Collaborators and Investigators

Sponsor: East Carolina University

  • Swati Surkar, PRINCIPAL_INVESTIGATOR, East Carolina University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-12-18
Study Completion Date2025-05-30

Study Record Updates

Study Start Date2021-12-18
Study Completion Date2025-05-30

Terms related to this study

Keywords Provided by Researchers

  • Cerebral palsy
  • Bimanual coordination
  • Corticospinal excitability

Additional Relevant MeSH Terms

  • Unilateral Cerebral Palsy
  • Hemiplegic Cerebral Palsy
  • Remote Ischemic Conditioning