Resistance Exercise Combined With Protein Supplementation in People With Pancreatic Cancer: The RE-BUILD Trial

Eligibility Criteria

• * Non-metastatic pancreatic cancer patients initiating neoadjuvant chemotherapy.
• * Ability to understand and the willingness to sign a written informed consent document.
• * Over the age of 18 years; children under the age of 18 will be excluded due to rarity of disease.
• * Speak English or Spanish.
• * Able to provide physician clearance to participate in the exercise program.
• * Able to initiate a supervised exercise program (free from any cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity).
• * Currently participate in less than or equal to 60 minutes of structured moderate or vigorous exercise/week.
• * Does not smoke (no smoking during previous 12 months).
• * Willing to travel to DFCI for assessments.
• * Patients should not have any uncontrolled illness including ongoing or active infection, uncontrolled diabetes, hypertension or thyroid disease.
• * Patients may not be receiving any other investigational agents.
• * Patients with other active malignancies are ineligible for this study.
• * Patients with metastatic disease.
• * History of any musculoskeletal, cardiorespiratory or neurological diseases that preclude the participation in exercise.
• * Patients expected to receive other cancer directed treatments during the study and assessment period.
• * Participates in more than 60 minutes of structured moderate or vigorous exercise/week.
• * Currently smokes.
• * Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study.
• * Is unable to travel to DFCI for assessments.
• * Patients who are pregnant due to the unknown effects of exercise on the developing fetus.