RECRUITING

A Study of Stellate Ganglion Block for Prevention of Atrial Fibrillation

Conditions

Quick Navigation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to test if a nerve block procedure called a stellate ganglion block can help decrease the chance of atrial fibrillation after surgery. Atrial fibrillation is the abnormal, fast beating of the upper chambers of the heart. Stellate ganglion blockade has shown to decrease other types of abnormal heart rhythms as well as decrease the chance of atrial fibrillation.

Official Title

Stellate Ganglion Blockade for the Prevention of Atrial Fibrillation After Cardiac Surgery: A Randomized Placebo-Controlled Trial

Quick Facts

Study Start:2023-04-19

Study Completion:2025-12

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05357690

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Patient presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota. * Patients scheduled to undergo mitral or aortic valve surgery with or without coronary artery bypass grafting.	* Patients with a history of permanent atrial fibrillation, left or right ventricular assist device implantation or explantation. * Patients with procedures not requiring cardiopulmonary bypass. * Patients with procedures requiring deep hypothermic circulatory arrest. * Patients with active infection or sepsis. * Pre-operative immunosuppressive medication use (including steroid use). * Pre-operative anti-arrhythmic medication use (aside from beta-blockers). * Patients with Immunodeficiency syndrome. * Patients with known neurologic disorder. * Patients requiring left internal jugular central line placement. * Performance of Maze procedures or left atrial appendage ligation procedures will not exclude patients from potential enrollment as atrial fibrillation still occurs postoperatively while the scarring from the Maze procedure forms.

Inclusion Criteria

Exclusion Criteria

* Patient presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota.
* Patients scheduled to undergo mitral or aortic valve surgery with or without coronary artery bypass grafting.

* Patients with a history of permanent atrial fibrillation, left or right ventricular assist device implantation or explantation.
* Patients with procedures not requiring cardiopulmonary bypass.
* Patients with procedures requiring deep hypothermic circulatory arrest.
* Patients with active infection or sepsis.
* Pre-operative immunosuppressive medication use (including steroid use).
* Pre-operative anti-arrhythmic medication use (aside from beta-blockers).
* Patients with Immunodeficiency syndrome.
* Patients with known neurologic disorder.
* Patients requiring left internal jugular central line placement.
* Performance of Maze procedures or left atrial appendage ligation procedures will not exclude patients from potential enrollment as atrial fibrillation still occurs postoperatively while the scarring from the Maze procedure forms.

Contacts and Locations

Principal Investigator

Erica Wittwer, MD

PRINCIPAL_INVESTIGATOR

Mayo Clinic

Study Locations (Sites)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

United States

Collaborators and Investigators

Sponsor: Mayo Clinic

Erica Wittwer, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-19

Study Completion Date2025-12

Study Record Updates

Study Start Date2023-04-19

Study Completion Date2025-12

Terms related to this study

Additional Relevant MeSH Terms

Atrial Fibrillation