PV Loop & Coarctation Study

Description

Coarctation of the aorta accounts for 4-7% of all congenital heart disease. While stent therapy, when feasible, is the standard of care for coarctation, it may not completely improve the work (and afterload) of the heart due to its effects on the elasticity of the aorta. This study will provide the information needed to understand the effects of current management on the cardiac mechanics and work.

Conditions

Coarctation of Aorta

Study Overview

Study Details

Study overview

Coarctation of the aorta accounts for 4-7% of all congenital heart disease. While stent therapy, when feasible, is the standard of care for coarctation, it may not completely improve the work (and afterload) of the heart due to its effects on the elasticity of the aorta. This study will provide the information needed to understand the effects of current management on the cardiac mechanics and work.

Assessment of the Impact of Transcatheter Stenting of Aortic Coarctation on the Left Ventricular Afterload and Work Using Left Ventricular Pressure Volume Loops

PV Loop & Coarctation Study

Condition
Coarctation of Aorta
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Children's Hospital of Los Angeles, Los Angeles, California, United States, 90027

Boston

Children's Hospital of Boston, Boston, Massachusetts, United States, 02115

Grand Rapids

Helen DeVos Children's Hospital, Grand Rapids, Michigan, United States, 49503

Minneapolis

University of Minnesota, Minneapolis, Minnesota, United States, 55455

Kansas City

Children's Mercy Hospital, Kansas City, Missouri, United States, 64108

Cincinnati

Cincinnati Children's Hospital, Cincinnati, Ohio, United States, 45229

Dallas

University of Texas-Southwestern, Dallas, Texas, United States, 75390

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Children 6 years of age and older and adults of all races and both sexes referred for elective cardiac catheterization and stent therapy for coarctation
  • * Those who provide informed consent for study participant.
  • * Children who undergo other interventions in addition to the coarctation
  • * Children with single ventricle physiology.
  • * Renal impairment
  • * Participant unwilling to sign a consent form.

Ages Eligible for Study

6 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Minnesota,

Gurumurthy Hiremath, PRINCIPAL_INVESTIGATOR, University of Minnesota

Study Record Dates

2026-12-31