Empiric Versus Selective Prevention Strategies for Kidney Stone Disease

Description

The aims of this study are to 1) Conduct a randomized clinical trial of selective versus empiric diet plus pharmacologic therapy in high-risk stone formers and 2) Determine adverse effects from, and adherence to selective and empiric strategies.

Conditions

Kidney Stones, Nephrolithiasis

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Study Overview

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Study Details

Study overview

The aims of this study are to 1) Conduct a randomized clinical trial of selective versus empiric diet plus pharmacologic therapy in high-risk stone formers and 2) Determine adverse effects from, and adherence to selective and empiric strategies.

Randomized Trial of Empiric Versus Selective Prevention Strategies for Kidney Stone Disease

Empiric Versus Selective Prevention Strategies for Kidney Stone Disease

Condition
Kidney Stones
Intervention / Treatment

-

Contacts and Locations

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Two or more symptomatic kidney stone events in the last 5 years
  • * Adult
  • * Medullary sponge kidney or renal tubular acidosis
  • * Untreated urinary obstruction
  • * Primary hyperparathyroidism
  • * Primary hyperoxaluria
  • * Pregnancy
  • * Inflammatory bowel disease or bowel resection
  • * Sarcoidosis
  • * Cystinuria
  • * Prior stone composition with uric acid, struvite, cystine, carbonate apatite
  • * Use of specific medications (thiazides, topiramate, xanthine oxidase inhibitors, citrate, bicarbonate)
  • * Chronic kidney disease stage 3 or higher (eGFR\<60)
  • * Gouty arthritis or 3 gout episodes in 1 year
  • * Known allergy to study medications
  • * Hypokalemia or hyponatremia at screening.
  • * Age \< 18 years

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Vanderbilt University Medical Center,

Ryan Hsi, MD, PRINCIPAL_INVESTIGATOR, Vanderbilt University Medical Center

Study Record Dates

2026-03-31