RECRUITING

FAPI PET for Lung Fibrosis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a prospective exploratory biodistribution study in patients with interstitial lung disease (ILD). The purpose of this research study is to determine where and to which degree the FAPI tracer (68Ga-FAPI-46) accumulates in normal and fibrotic lung tissues of patients with interstitial lung disease. The study will include patients with interstitial lung disease who have or will initiate a new ILD medication OR will undergo tissue biopsy or surgery of the lung. The study will include 30 patients, the upper limit for PET imaging studies conducted under the Radioactive Drug Research Committee (RDRC) purview. Participants will be injected with up to 7 mCi of 68-GaFAPi and will undergo one PET/CT scan and one High Resolution CT of the lungs. The study is sponsored by Ahmanson Translational Theranostic Division at UCLA.

Official Title

PET Study of 68Ga-FAPi-46 in Patients With Interstitial Lung Disease: an Exploratory Biodistribution Study With Histopathology Validation.

Quick Facts

Study Start:2021-11-16
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05365802

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Hamzah Alam, BS
CONTACT
3102067372
HAlam@mednet.ucla.edu
Contreras M Maria, BS
CONTACT
3102067372
MMContreras@mednet.ucla.edu

Principal Investigator

Jeremie Calais, MD
PRINCIPAL_INVESTIGATOR
Clinical Research Director, Ahmanson Translational Theranostics

Study Locations (Sites)

UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095
United States

Collaborators and Investigators

Sponsor: University of California, Los Angeles

  • Jeremie Calais, MD, PRINCIPAL_INVESTIGATOR, Clinical Research Director, Ahmanson Translational Theranostics

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-11-16
Study Completion Date2026-12

Study Record Updates

Study Start Date2021-11-16
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • interstitial lung disease
  • pulmonary fibrosis
  • 68Ga-FAPi-46

Additional Relevant MeSH Terms

  • Interstitial Lung Disease
  • Idiopathic Interstitial Pneumonias
  • Drug-Induced Pneumonitis
  • Hypersensitivity Pneumonitis
  • Radiation Pneumonitis
  • Pneumoconiosis
  • Pulmonary Fibrosis