Lesion Composition and Quantitative Imaging Analysis on Breast Cancer Diagnosis

Description

The objective is to better identify suspicious breast lesions that need to be biopsied for malignancy in women currently recommended for biopsy. The long-term goal is to reduce unnecessary biopsies and increase biopsy yield. To do this, the investigators have developed an innovative way to use FDA-approved breast imaging protocols to acquire multispectral images to measure the composition of suspicious breast lesions. The central hypothesis is that breast tissue composition in combination with analysis of morphological and textural tissue characteristics on digital breast tomosynthesis (DBT) imaging will yield significantly higher breast cancer specificity than conventional interpretation of DBT alone.

Conditions

Breast Cancer

Study Overview

Study Details

Study overview

The objective is to better identify suspicious breast lesions that need to be biopsied for malignancy in women currently recommended for biopsy. The long-term goal is to reduce unnecessary biopsies and increase biopsy yield. To do this, the investigators have developed an innovative way to use FDA-approved breast imaging protocols to acquire multispectral images to measure the composition of suspicious breast lesions. The central hypothesis is that breast tissue composition in combination with analysis of morphological and textural tissue characteristics on digital breast tomosynthesis (DBT) imaging will yield significantly higher breast cancer specificity than conventional interpretation of DBT alone.

Lesion Composition and Quantitative Imaging Analysis on Breast Cancer Diagnosis

Lesion Composition and Quantitative Imaging Analysis on Breast Cancer Diagnosis

Condition
Breast Cancer
Intervention / Treatment

-

Contacts and Locations

Tampa

H. Lee Moffitt Cancer Center & Research Institute, Inc., Tampa, Florida, United States, 33612

Hilo

Hawaii Radiology Associates, LTD (East Hawaii Women's Imaging Center), Hilo, Hawaii, United States, 96720

Honolulu

The Queen's Medical Center, Honolulu, Hawaii, United States, 96822

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Had a recent diagnostic mammogram with a BI-RADS diagnostic score 4 or 5 assigned by a radiologist (BIRADS are standardized mammography assessment categories: 4 is for "Suspicious abnormality", 5 is for "Highly suggestive of malignancy".
  • * Have not had biopsy
  • * Pregnant or breast feeding
  • * History of breast cancer or a mastectomy (removal of the breast) with Systemic Therapy (ex. Chemotherapy, hormones and hormone inhibitors, etc.).

Ages Eligible for Study

20 Years to 85 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Hawaii,

John A Shepherd, PhD, PRINCIPAL_INVESTIGATOR, University of Hawaii Cancer Research Center

Study Record Dates

2026-07