Long-term COVID and Rehabilitation

Description

The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by combating the oxidative stress and inflammation associated with aging and further induced by COVID-19. The investigators expected outcomes will have an important positive impact because they will provide scientifically sound recommendations for rehabilitation to improve vascular endothelial function and minimize the long-term consequences of COVID-19.

Conditions

Long-COVID

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Study Overview

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Study Details

Study overview

The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by combating the oxidative stress and inflammation associated with aging and further induced by COVID-19. The investigators expected outcomes will have an important positive impact because they will provide scientifically sound recommendations for rehabilitation to improve vascular endothelial function and minimize the long-term consequences of COVID-19.

Evaluating the Long-term Health Consequences of COVID-19 and Rehabilitation Therapies to Speed Convalescence

Long-term COVID and Rehabilitation

Condition
Long-COVID
Intervention / Treatment

-

Contacts and Locations

Salt Lake City

VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City, Utah, United States, 84148-0001

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 50 years of age or greater
  • * Long-COVID and COVID-recovered patients must have SARS-CoV-19 positive test near the time of COVID-19 diagnosis
  • * Long-COVID and COVID-recovered patients must be 3-12 months post-initial COVID-19 diagnosis
  • * Ability to sign informed consent
  • * BMI \>45 kg/m2
  • * Unstable (\<6 months) or severe coronary artery disease (CAD-RADS score = 4A), peripheral artery disease (Ankle Brachial Index \<0.40), cerebrovascular disease (identified by previous stroke in last 12 months), severe COPD (=Stage III), uncontrolled hypertension (\>160/100 mmHg), chronic kidney disease requiring dialysis, severe renal insufficiency (creatinine clearance \<30 by the Cockcroft-Gault formula), Alzheimer's disease, dementia
  • * Orthopedic limitations that would prohibit exercise
  • * \[Current smokers and individuals that stopped smoking in the last 10 years\]
  • * Already taking Mito-Q or unwilling to cease dietary supplements for participation
  • * Any other condition or event considered exclusionary by the PIs or a physician

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

VA Office of Research and Development,

Joel Douglas Trinity, PhD, PRINCIPAL_INVESTIGATOR, VA Salt Lake City Health Care System, Salt Lake City, UT

Study Record Dates

2028-10-31