Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain

Description

The investigators aim to conduct a fully powered randomized controlled trial to compare the efficacy of two symptom management programs for older adults with early cognitive decline (either self-reported or confirmed by testing) and chronic pain, Active Brains 1 and Active Brains 2. The investigators will assess how each program may help in improving multimodal physical, cognitive and emotional function. The investigators will also assess whether improvements in outcomes from the two programs are maintained through 6-months follow-up. The investigators will also explore whether improvements in outcomes are mediated by nonadaptive pain reactions, adaptive coping, social factors and compensatory strategies and modified by demographic and clinical predictors. Both programs will be delivered virtually (Zoom).

Conditions

Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity

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Study Overview

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Study Details

Study overview

The investigators aim to conduct a fully powered randomized controlled trial to compare the efficacy of two symptom management programs for older adults with early cognitive decline (either self-reported or confirmed by testing) and chronic pain, Active Brains 1 and Active Brains 2. The investigators will assess how each program may help in improving multimodal physical, cognitive and emotional function. The investigators will also assess whether improvements in outcomes from the two programs are maintained through 6-months follow-up. The investigators will also explore whether improvements in outcomes are mediated by nonadaptive pain reactions, adaptive coping, social factors and compensatory strategies and modified by demographic and clinical predictors. Both programs will be delivered virtually (Zoom).

Addressing the Chronic Pain-Early Cognitive Decline Comorbidity Among Older Adults; The Active Brains Study

Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain

Condition
Chronic Pain
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male and female outpatients, age 60 years or older
  • * Have nonmalignant chronic pain for more than 3 months
  • * Reports early cognitive decline (subjective or objective)
  • * Telephone Interview for Cognitive Status-30 score greater than or equal to 17
  • * Functional Activities Questionnaire score less than 9
  • * Able to perform a 6-minute walk test at an accelerated pace
  • * English fluency/literacy
  • * Willingness and ability to participate and use an ActiGraph watch and smartphone app to view and sync the step count and sleep data
  • * Free of concurrent psychotropic or pain medication for at least 2 weeks prior to initiation of treatment, OR stable on current psychotropic or pain medication for a minimum of 6 weeks and willing to maintain a stable dose
  • * Cleared by a medical doctor for study participation and no self-reported concerns about physical functioning on the revised Physical Activity Readiness Questionnaire (PAR-Q; score 0)
  • * Diagnosed with dementia or neurodegenerative disease
  • * Diagnosed with medical illness expected to worsen in the next 6 months
  • * Diagnosed with serious untreated mental illness (i.e., schizophrenia) or untreated substance use disorder
  • * Current suicidal ideation reported on self-report
  • * Engaging in regular mindfulness practice \> 45 min/week or has completed a course of cognitive behavioral therapy in the past 3 months
  • * Regular use of a digital-monitoring device
  • * Engagement in regular intensive physical exercise for \>30 minute daily

Ages Eligible for Study

60 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Massachusetts General Hospital,

Ana-Maria Vranceanu, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

2026-12-31