FMT in Uncomplicated Diverticulitis

Description

Fecal Microbiota Transplantation (FMT) is an established treatment for Clostridium difficile (C. diff) infection refractory to medical management. As C. diff infection usually arises due to significant disturbances in the gut microbiome, FMT is typically performed to restore a healthy microbiome among affected patients who have failed other treatments. Diverticulitis is a major, and often recurrent, source of morbidity in the U.S for which antibiotics and surgical resection constitute the only treatment options to date. Although alterations of the intestinal microbiome have also been shown among patients with diverticular disease, research on FMT in diverticulitis is sparse. The intended goal of this project is to determine the feasibility, effectiveness and safety of FMT in the treatment of uncomplicated diverticulitis, using clinical outcomes and microbiome analyses.

Conditions

Diverticulitis, Uncomplicated Diverticular Disease

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Study Overview

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Study Details

Study overview

Fecal Microbiota Transplantation (FMT) is an established treatment for Clostridium difficile (C. diff) infection refractory to medical management. As C. diff infection usually arises due to significant disturbances in the gut microbiome, FMT is typically performed to restore a healthy microbiome among affected patients who have failed other treatments. Diverticulitis is a major, and often recurrent, source of morbidity in the U.S for which antibiotics and surgical resection constitute the only treatment options to date. Although alterations of the intestinal microbiome have also been shown among patients with diverticular disease, research on FMT in diverticulitis is sparse. The intended goal of this project is to determine the feasibility, effectiveness and safety of FMT in the treatment of uncomplicated diverticulitis, using clinical outcomes and microbiome analyses.

Outcomes of Fecal Microbiota Transplantation (FMT) in Uncomplicated Diverticulitis: A Pilot Study

FMT in Uncomplicated Diverticulitis

Condition
Diverticulitis
Intervention / Treatment

-

Contacts and Locations

Worcester

UMASS Memorial Medical Center, Worcester, Massachusetts, United States, 01605

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age \>18
  • 2. One or more prior episode(s) of uncomplicated diverticulitis, as confirmed by imaging and clinical symptoms.
  • 3. Eligible for surgical resection
  • 1. Subjects \<18 years of age
  • 2. Patients with active diverticulitis flare
  • 3. Evidence of complicated diverticulitis (diverticulitis with abscess/phlegmon, bleeding, stricture, fistula or perforation) on imaging
  • 4. Prior fecal transplant
  • 5. Patients unable to provide informed consent
  • 6. Pregnant and/or breastfeeding women
  • 7. Prisoners
  • 8. Students
  • 9. Prior small or large bowel obstruction within the past year
  • 10. Prior major gastrointestinal or intra-abdominal surgery
  • 11. Any major illness or condition that may substantially increase risks to the recipient based on the investigator's judgment.
  • 12. Sexually active women who adhere to natural family planning alone

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Justin Maykel,

Justin A Maykel, MD, PRINCIPAL_INVESTIGATOR, UMass Chan Medical School

Study Record Dates

2025-05-30