TERMINATED

A Study of BGB-24714 as Monotherapy and With Combination Therapies in Participants With Solid Tumors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to understand how safe and well-tolerated a drug called BGB-24714 is when used alone, or in combination with chemotherapy or radiation therapy, for people with advanced or spreading solid tumors. The main objective is to identify the highest tolerable dose or the highest administered dose of BGB-24714. Additionally, the study aims to identify the most suitable doses for further investigation in larger groups of participants.

Official Title

A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of Second Mitochondrial-derived Activator of Caspases Mimetic BGB-24714 as Monotherapy and With Combination Therapies in Patients With Solid Tumors

Quick Facts

Study Start:2022-07-06
Study Completion:2025-07-25
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:TERMINATED

Study ID

NCT05381909

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. 1. Active leptomeningeal disease or uncontrolled, untreated brain metastasis.
  2. 2. Any malignancy ≤ 3 years before the first dose of study drug(s) except for the specific cancer under investigation in this study and any locally recurring cancer that has been treated with curative intent
  3. 3. Any condition that required systemic treatment with either corticosteroids or other immunosuppressive medication ≤ 14 days before the first dose of study drug(s).
  4. 4. Clinically significant infection requiring systemic therapy ≤ 14 days before the first dose of study drug(s).
  5. 5. Prior exposure to agents with second mitochondria-derived activator of caspases (SMAC) mimetics, or other Inhibitors of apoptosis proteins (IAPs) antagonists.

Contacts and Locations

Study Locations (Sites)

Banner Md Anderson Cancer Center
Gilbert, Arizona, 85234-2165
United States
Florida Cancer Specialist (Scri) Sarasota
Sarasota, Florida, 34232
United States
Scri Florida Cancer Specialists North
St. Petersburg, Florida, 33705-1449
United States
Scri Florida Cancer Specialist East
West Palm Beach, Florida, 33401-3406
United States
Massachusetts General Hospital
Boston, Massachusetts, 02114
United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201-2013
United States
Hackensack University Medical Center
Hackensack, New Jersey, 07601-1915
United States
Upmc Hillman Cancer Center(Univ of Pittsburgh)
Pittsburgh, Pennsylvania, 15232-1309
United States
Sanford Cancer Center
Sioux Falls, South Dakota, 57104-4663
United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105-2108
United States
Tennessee Oncology, Pllc Nashville
Nashville, Tennessee, 37203
United States
Mary Crowley Cancer Research
Dallas, Texas, 75230
United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390-7208
United States
The University of Texas Md Anderson Cancer Center (Department Gi Medical Oncology)
Houston, Texas, 77030-4000
United States
Intermountain Healthcare
Salt Lake City, Utah, 84143
United States
Next Virginia
Fairfax, Virginia, 22031
United States
University of Washington
Seattle, Washington, 98195
United States

Collaborators and Investigators

Sponsor: BeiGene

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-07-06
Study Completion Date2025-07-25

Study Record Updates

Study Start Date2022-07-06
Study Completion Date2025-07-25

Terms related to this study

Keywords Provided by Researchers

  • Solid tumors
  • Advanced Solid Tumors
  • Metastatic Solid Tumors

Additional Relevant MeSH Terms

  • Solid Tumor, Adult