RECRUITING

Feasibility of Cell-Free DNA Liquid Biopsy in Screening High-Risk Patients for Lung Cancer

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This clinical trial investigates how practical and doable (feasibility) cell-free deoxyribonucleic acid (DNA) liquid biopsy is in screening high-risk patients for lung cancer. Currently, a low dose computed tomography (CT) scan is used to screen for lung cancer, however, due to various factors, few high-risk patients are screened. Liquid biopsy utilizes technology that can detect small amounts of DNA shed by cancer cells and may be able to spot lung cancer at an earlier stage. If a positive result comes back from the liquid biopsy, a patient may be more willing to get a low dose CT (LDCT) scan, possibly confirming the biopsy's findings and thus leading to more early lung cancer detection.

Official Title

Feasibility Study of Lung Cancer Screening Using Cell-Free DNA Liquid Biopsy At Home in High-Risk Current and Former Smokers

Quick Facts

Study Start:2022-07-29
Study Completion:2026-01-28
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05384769

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Documented written informed consent of the participant.
  2. * Age 50-80 years.
  3. * Smoking history of \>= 20 pack-years and if quit, quit within 15 years.
  4. * Received referral for counseling for lung cancer screening and would qualify for LDCT.
  5. * Health Insurance that will pay for a LDCT for lung cancer screening at either City of Hope Duarte, Newport Beach (Newport Diagnostic Imaging), or Lancaster (Renaissance Imaging/Antelope Valley Outpatient Imaging Center).
  6. * Willingness to provide blood sample.
  7. * English speaking.
  8. * Consent to undergo lung cancer screening with either liquid biopsy (LB) or LDCT.
  1. * Symptoms of lung cancer.
  2. * Chest CT scan or chest positron emission tomography (PET)/CT within 12 months.
  3. * Any cancer diagnosis within past 5 years, excluding non-melanoma skin cancer.
  4. * Unable to undergo LDCT at either City of Hope Duarte, Newport Beach, or Lancaster.

Contacts and Locations

Study Contact

Dan Raz, MD
CONTACT
626-359-8111
draz@coh.org

Principal Investigator

Dan Raz, MD
PRINCIPAL_INVESTIGATOR
City of Hope Medical Center

Study Locations (Sites)

City of Hope Medical Center
Duarte, California, 91010
United States

Collaborators and Investigators

Sponsor: City of Hope Medical Center

  • Dan Raz, MD, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-07-29
Study Completion Date2026-01-28

Study Record Updates

Study Start Date2022-07-29
Study Completion Date2026-01-28

Terms related to this study

Additional Relevant MeSH Terms

  • Lung Carcinoma