CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance

Description

The incidence of type 2 diabetes (T2D) in children is increasing, paralleling the rising incidence of obesity. Preventing children and adolescents from developing T2D is critical. The health benefits of lifestyle modifications are well documented in this population, but success rates are low. Obesity in children and adolescents increases the risk of not only T2D but other complications as well, such as hypertension, dyslipidemias and more. The investigators hypothesize that having real-time glucose data with the use of a continuous glucose monitor (CGM) in obese patients with impaired glucose tolerance will improve adherence to lifestyle modifications. As a result, a decrease in body mass index (BMI) is expected with subsequent improvement in insulin sensitivity, thus reducing risk of obesity-related complications later in childhood/adolescence and adulthood.

Conditions

Impaired Glucose Tolerance

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Study Overview

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Study Details

Study overview

The incidence of type 2 diabetes (T2D) in children is increasing, paralleling the rising incidence of obesity. Preventing children and adolescents from developing T2D is critical. The health benefits of lifestyle modifications are well documented in this population, but success rates are low. Obesity in children and adolescents increases the risk of not only T2D but other complications as well, such as hypertension, dyslipidemias and more. The investigators hypothesize that having real-time glucose data with the use of a continuous glucose monitor (CGM) in obese patients with impaired glucose tolerance will improve adherence to lifestyle modifications. As a result, a decrease in body mass index (BMI) is expected with subsequent improvement in insulin sensitivity, thus reducing risk of obesity-related complications later in childhood/adolescence and adulthood.

Effect of Adding Continuous Glucose Monitoring (CGM) to Lifestyle Changes on Insulin Sensitivity in Patients With Impaired Glucose Tolerance

CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance

Condition
Impaired Glucose Tolerance
Intervention / Treatment

-

Contacts and Locations

Jacksonville

Nemours Children's Clinic, Jacksonville, Florida, United States, 32207

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Children 10 to \<17 years old (i.e., before their 17th birthday)
  • 2. Impaired glucose tolerance based on standardized oral glucose tolerance test (OGTT) or fasting glucose per American Diabetes Association criteria,
  • 3. Overweight or obese (BMI ≥85th percentile for age/sex)
  • 4. Patients are pubertal, defined as females with breast Tanner stage II or above, or males with testicular volume ≥4 mL
  • 1. Existing diagnosis of type 1 or type 2 diabetes
  • 2. Prepubertal
  • 3. Taking medications that affect insulin sensitivity (e.g.,chronic corticosteroids whether systemic or inhaled). Metformin allowed if stable dose.
  • 4. Patients and/or families not willing to wear the CGM for the duration of the study period or lack of compliance after recruitment

Ages Eligible for Study

10 Years to 16 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Nemours Children's Clinic,

Larry A Fox, MD, PRINCIPAL_INVESTIGATOR, Nemours Children's Health

Study Record Dates

2025-03-31