Sodium Lowering Vascular Effects Trial

Description

The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension. Findings from this study will fill the knowledge gap on the underlying mechanisms of dietary sodium intake on cardiovascular disease risk in addition to blood pressure and could provide further evidence on sodium reduction for the prevention of cardiovascular disease.

Conditions

Endothelial Dysfunction, Vascular Stiffness, Left Ventricular Hypertrophy, Left Ventricular Dysfunction

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Study Overview

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Study Details

Study overview

The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension. Findings from this study will fill the knowledge gap on the underlying mechanisms of dietary sodium intake on cardiovascular disease risk in addition to blood pressure and could provide further evidence on sodium reduction for the prevention of cardiovascular disease.

A Mechanistic Trial of Dietary Sodium Reduction on Vascular Structure and Function

Sodium Lowering Vascular Effects Trial

Condition
Endothelial Dysfunction
Intervention / Treatment

-

Contacts and Locations

New Orleans

Tulane University Office of Health Research, New Orleans, Louisiana, United States, 70112

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Men or women aged ≥40 years. Individuals \<40 years are at a low risk for clinical and subclinical CVD
  • * Elevated BP or hypertension (systolic BP ≥120 mmHg and diastolic BP ≥80 mmHg with or without use of antihypertensive medications)
  • * Glomerular filtration rate (eGFR) \<30 or end-stage renal disease (kidney transplant or chronic dialysis)
  • * History of cardiovascular disease
  • * Shift worker or regularly work at night
  • * Cancer requiring chemotherapy or radiation treatment in the previous two years
  • * Current pregnancy or breastfeeding or plans to become pregnant during the study
  • * Consumption of ≥21 alcoholic drinks/week
  • * Current participation in another lifestyle intervention or drug trial
  • * Current residence or planned residence that makes it difficult to meet trial requirements
  • * Other concerns regarding ability to meet trial requirements (at the discretion of the study coordinator)

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Tulane University,

Katherine T Mills, PhD, PRINCIPAL_INVESTIGATOR, Tulane University

Study Record Dates

2026-12-31