ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

Description

ASCEND researchers are partnering with families of children who receive extracorporeal membrane oxygenation (ECMO) after a sudden failure of breathing named pediatric acute respiratory distress syndrome (PARDS). ECMO is a life support technology that uses an artificial lung outside of the body to do the lung's work. ASCEND has two objectives. The first objective is to learn more about children's abilities and quality of life among ECMO-supported children in the year after they leave the pediatric intensive care unit. The second objective is to compare short and long-term patient outcomes in two groups of children: one group managed with a mechanical ventilation protocol that reserves the use of extracorporeal membrane oxygenation (ECMO) until protocol failure to another group supported on ECMO per usual care.

Conditions

Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation

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Study Details

Study overview

ASCEND researchers are partnering with families of children who receive extracorporeal membrane oxygenation (ECMO) after a sudden failure of breathing named pediatric acute respiratory distress syndrome (PARDS). ECMO is a life support technology that uses an artificial lung outside of the body to do the lung's work. ASCEND has two objectives. The first objective is to learn more about children's abilities and quality of life among ECMO-supported children in the year after they leave the pediatric intensive care unit. The second objective is to compare short and long-term patient outcomes in two groups of children: one group managed with a mechanical ventilation protocol that reserves the use of extracorporeal membrane oxygenation (ECMO) until protocol failure to another group supported on ECMO per usual care.

ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

Condition
Acute Respiratory Distress Syndrome
Intervention / Treatment

-

Contacts and Locations

Ann Arbor

University of Michigan - Mott Children's Hospital, Ann Arbor, Michigan, United States, 48109

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Time between intubation and ECMO cannulation is less than 240 hours (10 days)
  • * ECMO support type is respiratory (VV or VA cannulation)
  • * Chest radiograph with bilateral lung disease
  • * Moderate or severe pediatric ARDS as measured by oxygenation index or oxygen saturation index after intubation and prior to ECMO cannulation:
  • * Previously enrolled in PROSpect
  • * Perinatal related lung disease
  • * Congenital diaphragmatic hernia or congenital/acquired diaphragm paralysis
  • * Respiratory failure caused by cardiac failure or fluid overload
  • * Cyanotic congenital heart disease
  • * Cardiomyopathy
  • * Primary pulmonary hypertension (PAH)
  • * Unilateral lung disease
  • * Intubated for status asthmaticus
  • * Obstructive airway disease
  • * Bronchiolitis obliterans
  • * Post hematopoietic stem cell transplant
  • * Post lung transplant
  • * Home ventilator dependent
  • * Neuromuscular respiratory failure
  • * Head trauma: (managed with hyperventilation)
  • * Intracranial bleeding
  • * Unstable spine, femur or pelvic fractures
  • * Acute abdominal process/open abdomen
  • * Family/medical team have decided to not provide full support
  • * Enrolled in interventional clinical trial: not approved for co-enrollment; does not include cancer protocols.
  • * Known pregnancy

Ages Eligible for Study

14 Days to 20 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Michigan,

Ryan Barbaro, MD, PRINCIPAL_INVESTIGATOR, University of Michigan

Study Record Dates

2026-06