COMPLETED

Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.

Official Title

Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct

Quick Facts

Study Start:2022-09-26
Study Completion:2024-08-23
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05390580

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 99 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult patients who present with acute ischemic strokes due to large vessel occlusions
  1. * \<18 years old
  2. * patients with presumed chronic large vessel occlusions
  3. * NIHSS\<6
  4. * pre-morbid modified Rankin score (mRS) \>2
  5. * unable to initiate treatment under 36 hours from symptom discovery
  6. * Chronic or severe infection
  7. * life expectancy \<3 months
  8. * patients' undergoing active cancer or immunosuppressive/modulating therapy
  9. * patients with sustained bradycardia on arrival with a heart rate \<50 beats per minute.

Contacts and Locations

Study Locations (Sites)

Washington University in St. Louis School of Medicine
St Louis, Missouri, 63110
United States

Collaborators and Investigators

Sponsor: Washington University School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-09-26
Study Completion Date2024-08-23

Study Record Updates

Study Start Date2022-09-26
Study Completion Date2024-08-23

Terms related to this study

Keywords Provided by Researchers

  • acute ischemic stroke
  • cytokines
  • large vessel occlusion
  • vagal nerve stimulator

Additional Relevant MeSH Terms

  • Acute Ischemic Stroke