MicroRNA Regulation of Chronic Inflammation During Aging

Description

This is an observational study enrolling healthy individuals aged 18-35 and 65y and older to determine the health of immune cells in the blood and how these cells create inflammation and effect health as we age. It is hoped that once the nature of this relationship has been discovered we can more effectively design therapies to reduce this inflammation. The enrollment goal is 40 participants. The study will occur over the course of 1 month which will include a screening visit and a second visit where the participants will undergo an oral glucose tolerance test, blood draws and leg strength \& exercise tests.

Conditions

Chronic Inflammation

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Study Overview

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Study Details

Study overview

This is an observational study enrolling healthy individuals aged 18-35 and 65y and older to determine the health of immune cells in the blood and how these cells create inflammation and effect health as we age. It is hoped that once the nature of this relationship has been discovered we can more effectively design therapies to reduce this inflammation. The enrollment goal is 40 participants. The study will occur over the course of 1 month which will include a screening visit and a second visit where the participants will undergo an oral glucose tolerance test, blood draws and leg strength \& exercise tests.

MicroRNA Regulation of Chronic Inflammation During Aging

MicroRNA Regulation of Chronic Inflammation During Aging

Condition
Chronic Inflammation
Intervention / Treatment

-

Contacts and Locations

Salt Lake City

The University of Utah, Salt Lake City, Utah, United States, 84112

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age between 18 - 35y; 65y and older
  • 2. BMI: \<30 kg/m2
  • 3. Ability to sign informed consent
  • 4. For older participant group: Clinical Frailty Scale score \< 3 and Mini-Cog score \> 3
  • 5. Good general medical health, ambulatory and in independent living setting
  • * History of cardiovascular disease (e.g., CHF, CAD, MI, CVA)
  • * History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted)
  • * History of kidney disease or failure (CKD \> stage 4)
  • * History of vascular disease
  • * Uncontrolled hypertension - Elevated systolic pressure \>150 or a diastolic blood pressure \> 100
  • * Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
  • * Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids will be permitted)
  • * Chronic anti-inflammatory medication use (≥ 2 weeks) within 4 weeks of enrollment
  • * Chronic inflammatory conditions (e.g., Rheumatoid Arthritis, Crohn's, fibromyalgia, lupus, colitis) HIV, Hepatitis B and C
  • * History of stroke with motor disability
  • * A recent history (\<12 months) of GI bleed
  • * History of liver disease or AST/ALT 2 times above the normal limit
  • * History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)
  • * Current smokers or current tobacco use
  • * Current pregnancy as determined by positive pregnancy test
  • * Any staff members who report directly to the principal investigators.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Utah,

Micah Drummond, PRINCIPAL_INVESTIGATOR, The University of Utah

Study Record Dates

2028-01-01