Botulinum Toxin Therapy in Hidradenitis Suppurativa

Description

This study will build on data from mice and humans implicating TRPV1 nociceptors in the pathogenesis of the type-17 chronic inflammatory skin disease Hidradenitis Suppurativa (HS). In this study, the investigators will test the hypothesis that inhibiting neuropeptide activity with botulinum toxin reduces pathogenic inflammation.

Conditions

Hidradenitis Suppurativa, Hyperhidrosis

Study Overview

Study Details

Study overview

This study will build on data from mice and humans implicating TRPV1 nociceptors in the pathogenesis of the type-17 chronic inflammatory skin disease Hidradenitis Suppurativa (HS). In this study, the investigators will test the hypothesis that inhibiting neuropeptide activity with botulinum toxin reduces pathogenic inflammation.

Targeting Nociceptors in Hidradenitis Suppurativa

Botulinum Toxin Therapy in Hidradenitis Suppurativa

Condition
Hidradenitis Suppurativa
Intervention / Treatment

-

Contacts and Locations

Worcester

University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, 01605

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to 75 Years

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    University of Massachusetts, Worcester,

    Sarah K Whitley, MD PhD, PRINCIPAL_INVESTIGATOR, Assistant Professor of Dermatology

    Study Record Dates

    2028-04-30