RECRUITING

PRP in ACLR to Prevent PTOA

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is considered a 'pilot study' in terms of the lab analysis proposed.

Official Title

Platelet Rich Plasma (PRP) Treatment of the Anterior Cruciate Ligament Injured Knee to Decrease the Risk of Post-traumatic Osteoarthritis (PTOA): a Randomized Double-blind Controlled Trial

Quick Facts

Study Start:2022-06-27
Study Completion:2024-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05412381

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:14 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Acute ACL injury within 6 weeks of presentation
  2. * Age 14-50
  3. * Male or female
  4. * Meniscus injury that can be treated with meniscectomy or repair (the lack of meniscus injury will not exclude patients)
  1. * Prior ACL reconstruction
  2. * Prior cartilage repair procedure
  3. * Prior meniscus surgery within 12 months
  4. * Prior steroid, hyaluronic acid, or PRP injection within 6 months
  5. * Other ligament injury requiring repair
  6. * Any cartilage lesion requiring repair
  7. * Any cartilage lesion greater than grade 2 (partial thickness injury)
  8. * History of inflammatory arthritis or joint sepsis
  9. * Non English speakers

Contacts and Locations

Study Contact

Jessica Andres-Bergos, PhD
CONTACT
(917) 260-4694
andresbergosj@hss.edu

Study Locations (Sites)

Hospital for Special Surgery
New York, New York, 10021
United States

Collaborators and Investigators

Sponsor: Hospital for Special Surgery, New York

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-06-27
Study Completion Date2024-12-31

Study Record Updates

Study Start Date2022-06-27
Study Completion Date2024-12-31

Terms related to this study

Keywords Provided by Researchers

  • platelet-rich plasma
  • regenerative medicine
  • anterior cruciate ligament reconstruction
  • post-traumatic osteoarthritis

Additional Relevant MeSH Terms

  • Anterior Cruciate Ligament Injuries
  • Post-traumatic Osteoarthritis
  • PRP