PRP in ACLR to Prevent PTOA

Description

The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is considered a 'pilot study' in terms of the lab analysis proposed.

Conditions

Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, PRP

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Study Overview

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Study Details

Study overview

The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is considered a 'pilot study' in terms of the lab analysis proposed.

Platelet Rich Plasma (PRP) Treatment of the Anterior Cruciate Ligament Injured Knee to Decrease the Risk of Post-traumatic Osteoarthritis (PTOA): a Randomized Double-blind Controlled Trial

PRP in ACLR to Prevent PTOA

Condition
Anterior Cruciate Ligament Injuries
Intervention / Treatment

-

Contacts and Locations

New York

Hospital for Special Surgery, New York, New York, United States, 10021

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Acute ACL injury within 6 weeks of presentation
  • * Age 14-50
  • * Male or female
  • * Meniscus injury that can be treated with meniscectomy or repair (the lack of meniscus injury will not exclude patients)
  • * Prior ACL reconstruction
  • * Prior cartilage repair procedure
  • * Prior meniscus surgery within 12 months
  • * Prior steroid, hyaluronic acid, or PRP injection within 6 months
  • * Other ligament injury requiring repair
  • * Any cartilage lesion requiring repair
  • * Any cartilage lesion greater than grade 2 (partial thickness injury)
  • * History of inflammatory arthritis or joint sepsis
  • * Non English speakers

Ages Eligible for Study

14 Years to 50 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Hospital for Special Surgery, New York,

Study Record Dates

2024-12-31