Once Weekly Infant Corticosteroid Trial for DMD

Description

The hypothesis tested here is that a lower dose of intermittent oral corticosteroids (5mg/kg/week) will be equally effective to the 10mg/kg/week dose.

Conditions

Duchenne Muscular Dystrophy

Study Overview

Study Details

Study overview

The hypothesis tested here is that a lower dose of intermittent oral corticosteroids (5mg/kg/week) will be equally effective to the 10mg/kg/week dose.

Phase-2 Trial of 5mg/kg/Week Prednisolone in Young Boys With DMD

Once Weekly Infant Corticosteroid Trial for DMD

Condition
Duchenne Muscular Dystrophy
Intervention / Treatment

-

Contacts and Locations

Chicago

Lurie Children's Hospital of Chicago, Chicago, Illinois, United States, 60611

Cincinnati

University of Cincinnati, Cincinnati, Ohio, United States, 45220

Columbus

Nationwide Children's Hospital, Columbus, Ohio, United States, 43205

Dallas

University of Texas Southwestern, Dallas, Texas, United States, 75235

Richmond

Virginia Commonwealth University, Richmond, Virginia, United States, 23284

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects ages 1 month through 30 months
  • * Weakness consistent with Duchenne on exam, creatine kinase ≥ 20 times the upper limit of normal, and genetic mutation known to be causative for DMD.
  • * Prior treatment with Glucocorticosteroids

Ages Eligible for Study

1 Month to 30 Months

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Anne M. Connolly,

Anne Connolly, MD, PRINCIPAL_INVESTIGATOR, Nationwide Children's Hospital

Study Record Dates

2026-12-30