Assessment of the Ocular Microbiome in Health and Disease

Description

The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment. We will conduct a prospective, observational cohort study, including a longitudinal analysis of the ocular microbiome in adults.

Conditions

Microbial Colonization, Eye Diseases, Ophthalmopathy

Study Overview

Study Details

Study overview

The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment. We will conduct a prospective, observational cohort study, including a longitudinal analysis of the ocular microbiome in adults.

Assessment of the Ocular Microbiome in Health and Disease

Assessment of the Ocular Microbiome in Health and Disease

Condition
Microbial Colonization
Intervention / Treatment

-

Contacts and Locations

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18 years of age or older
  • * Provide informed consent
  • * Cohort A - normal eyes with no ocular disease
  • * Cohort B - primary open angle glaucoma/Ocular hypertension defined as mild glaucoma which is well controlled with no more than one drop of prostaglandin use daily for the past 6 months
  • * Cohort C - non-infectious keratopathy not using any prescription medication (OTC artificial tears are acceptable)
  • * Cohort D - Dry AMD (age related macular degeneration)
  • * Cohort E - Wet AMD
  • * Cohort F - diabetic retinopathy
  • * Prior ocular disease either of the anterior or posterior segment
  • * Any medical comorbidities except well controlled DH and HTN
  • * Unable to follow up with study procedures as described

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Vanderbilt University Medical Center,

Study Record Dates

2027-12-30