RECRUITING

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease. The main questions the study seeks to answer are: 1. Can LIFUP increase brain activity in the targeted area? 2. Can LIFUP improve memory in people with MCI and mild AD? 3. Can LIFUP improve connectivity of memory networks in the brain? Participants in this study will complete MRIs and memory testing, and receive Low Intensity Focused Ultrasound to a part of their brain involved in memory (the entorhinal cortex).

Official Title

Modulation of Hippocampal Circuitry and Memory Function with Focused Ultrasound in Amnestic MCI

Quick Facts

Study Start:2022-09-01
Study Completion:2026-07-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05417555

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Natalie Rotstein
CONTACT
‭(310) 794-0077‬
tfus@mednet.ucla.edu
Sabrina Halavi
CONTACT
‭(310) 794-0077‬
tfus@mednet.ucla.edu

Principal Investigator

Susan Y Bookheimer, PhD
PRINCIPAL_INVESTIGATOR
UCLA Psychiatry & Biobehavioral Sciences
Taylor P Kuhn, PhD
PRINCIPAL_INVESTIGATOR
UCLA Psychiatry & Biobehavioral Sciences

Study Locations (Sites)

UCLA Semel Institute for Neuroscience and Behavior
Los Angeles, California, 90024
United States

Collaborators and Investigators

Sponsor: University of California, Los Angeles

  • Susan Y Bookheimer, PhD, PRINCIPAL_INVESTIGATOR, UCLA Psychiatry & Biobehavioral Sciences
  • Taylor P Kuhn, PhD, PRINCIPAL_INVESTIGATOR, UCLA Psychiatry & Biobehavioral Sciences

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-09-01
Study Completion Date2026-07-31

Study Record Updates

Study Start Date2022-09-01
Study Completion Date2026-07-31

Terms related to this study

Keywords Provided by Researchers

  • deep brain stimulation (DBS)
  • transcranial focused ultrasound stimulation (tFUS)
  • memory
  • low-intensity focused ultrasound pulsation (LIFUP)
  • fMRI
  • mild cognitive impairment
  • mci
  • noninvasive brain stimulation (NIBS)
  • ultrasound
  • Alzheimer's Disease
  • Mild Alzheimer's

Additional Relevant MeSH Terms

  • Mild Cognitive Impairment
  • Amnestic Mild Cognitive Disorder
  • Deep Brain Stimulation
  • Mild Alzheimer's Disease