A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Description

The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.

Conditions

Lung Cancer, Lung Cancer Metastatic, Brain Metastases, Brain Metastases, Adult, Small-cell Lung Cancer, Small Cell Lung Carcinoma

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Study Overview

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Study Details

Study overview

The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.

A Single Arm Phase II Study Assessing Efficacy of Stereotactic Radiosurgery (SRS) for Brain Metastasis (BM) From Small Cell Lung Cancer (SCLC)

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Condition
Lung Cancer
Intervention / Treatment

-

Contacts and Locations

Hartford

Hartford Healthcare (Data Collection Only), Hartford, Connecticut, United States, 06102

Basking Ridge

Memorial Sloan Kettering at Basking Ridge, Basking Ridge, New Jersey, United States, 07920

Middletown

Memorial Sloan Kettering Monmouth, Middletown, New Jersey, United States, 07748

Montvale

Memorial Sloan Kettering Bergen, Montvale, New Jersey, United States, 07645

Commack

Memorial Sloan Kettering Suffolk - Commack, Commack, New York, United States, 11725

Harrison

Memorial Sloan Kettering Westchester, Harrison, New York, United States, 10604

New York

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York, United States, 10065

Rockville Centre

Memorial Sloan Kettering Nassau, Rockville Centre, New York, United States, 11553

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Histologic diagnosis of small cell lung cancer
  • * Radiographic diagnosis of up to 10 brain metastases on contrast-enhanced MRI
  • * Age 18 and above
  • * Performance status KPS 60-100/ECOG 0-2
  • * Female patients must be of non-reproductive potential or have a negative serum pregnancy test at the time of enrollment
  • * The patient or legally authorized representative is able to provide informed consent
  • * Unable to undergo contrast-enhanced MRI brain or spine
  • * Leptomeningeal disease confirmed on lumbar puncture, MRI brain, or MRI spine
  • * Pregnant or lactating women
  • * Prior brain-directed radiotherapy
  • * Uncontrolled systemic disease without reasonable systemic therapy options felt likely to result in death as observed on CT or PET/CT imaging, no more than 3 months before study enrollment

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Memorial Sloan Kettering Cancer Center,

Luke Pike, MD, PRINCIPAL_INVESTIGATOR, Memorial Sloan Kettering Cancer Center

Study Record Dates

2025-06-10