RECRUITING

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

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Conditions

Lung CancerLung Cancer MetastaticBrain MetastasesBrain Metastases, AdultSmall-cell Lung CancerSmall Cell Lung CarcinomaStereotactic Radiosurgerysmall cell lung cancer22-133Memorial Sloan Kettering Cancer Center

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.

Official Title

A Single Arm Phase II Study Assessing Efficacy of Stereotactic Radiosurgery (SRS) for Brain Metastasis (BM) From Small Cell Lung Cancer (SCLC)

Quick Facts

Study Start:2022-06-10
Study Completion:2025-06-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05419076

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Histologic diagnosis of small cell lung cancer
  2. * Radiographic diagnosis of up to 10 brain metastases on contrast-enhanced MRI
  3. * Age 18 and above
  4. * Performance status KPS 60-100/ECOG 0-2
  5. * Female patients must be of non-reproductive potential or have a negative serum pregnancy test at the time of enrollment
  6. * The patient or legally authorized representative is able to provide informed consent
  1. * Unable to undergo contrast-enhanced MRI brain or spine
  2. * Leptomeningeal disease confirmed on lumbar puncture, MRI brain, or MRI spine
  3. * Pregnant or lactating women
  4. * Prior brain-directed radiotherapy
  5. * Uncontrolled systemic disease without reasonable systemic therapy options felt likely to result in death as observed on CT or PET/CT imaging, no more than 3 months before study enrollment

Contacts and Locations

Study Contact

Luke Pike, MD
CONTACT
201-775-7604
PikeL@mskcc.org
Brandon Imber, MD
CONTACT
631-212-6346
imberb@mskcc.org

Principal Investigator

Luke Pike, MD
PRINCIPAL_INVESTIGATOR
Memorial Sloan Kettering Cancer Center

Study Locations (Sites)

Hartford Healthcare (Data Collection Only)
Hartford, Connecticut, 06102
United States
Memorial Sloan Kettering at Basking Ridge
Basking Ridge, New Jersey, 07920
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645
United States
Memorial Sloan Kettering Suffolk - Commack
Commack, New York, 11725
United States
Memorial Sloan Kettering Westchester
Harrison, New York, 10604
United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, 10065
United States
Memorial Sloan Kettering Nassau
Rockville Centre, New York, 11553
United States

Collaborators and Investigators

Sponsor: Memorial Sloan Kettering Cancer Center

  • Luke Pike, MD, PRINCIPAL_INVESTIGATOR, Memorial Sloan Kettering Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-06-10
Study Completion Date2025-06-10

Study Record Updates

Study Start Date2022-06-10
Study Completion Date2025-06-10

Terms related to this study

Keywords Provided by Researchers

  • Stereotactic Radiosurgery
  • small cell lung cancer
  • small cell lung carcinoma
  • lung cancer
  • lung cancer metastatic
  • brain metastases
  • 22-133
  • Memorial Sloan Kettering Cancer Center

Additional Relevant MeSH Terms

  • Lung Cancer
  • Lung Cancer Metastatic
  • Brain Metastases
  • Brain Metastases, Adult
  • Small-cell Lung Cancer
  • Small Cell Lung Carcinoma