Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome

Description

The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\~80%), present with chronic tachycardia and Orthostatic intolerance symptoms without any identifiable cause. In addition, non-specific symptoms such as fatigue, headache, and "brain fog", commonly described in POTS patients are also present in this novel condition, recently named post-COVID-19 tachycardia syndrome, POTS variant. Reduced Vagal activity and unresolved inflammation is post-COVID-19 POTS is hypothesized as the cause of Long COVID

Conditions

Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), Long COVID, SARS CoV 2 Infection

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Study Overview

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Study Details

Study overview

The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\~80%), present with chronic tachycardia and Orthostatic intolerance symptoms without any identifiable cause. In addition, non-specific symptoms such as fatigue, headache, and "brain fog", commonly described in POTS patients are also present in this novel condition, recently named post-COVID-19 tachycardia syndrome, POTS variant. Reduced Vagal activity and unresolved inflammation is post-COVID-19 POTS is hypothesized as the cause of Long COVID

Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome

Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome

Condition
Post-acute COVID-19 Syndrome
Intervention / Treatment

-

Contacts and Locations

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Prior RT-PCR-confirmed COVID-19 infection.
  • * Post-COVID-19 POTS will be defined as the presence of orthostatic tachycardia (\>30 bpm) and chronic (\>3 months) pre-syncopal symptoms.
  • * Heart Disease: Myocardial Infarction, angina, heart failure
  • * History of stroke, or transient ischemic attack
  • * Undergone an invasive procedure for CVD (coronary artery bypass graft, angioplasty, valve replacement, pacemaker placement or other vascular surgeries)
  • * Uncontrolled hypertension defined as persistent blood pressure \>140/90.
  • * Post-menopausal women.
  • * Diabetes Mellitus Type 1 or Type 2. ,
  • * Impaired Hepatic function
  • * Impaired renal function test (eGFR\<60 mL/min/1.73m2).
  • * Ongoing substance abuse.
  • * Mental conditions rendering a subject unable to understand the nature, scope and possible consequences of the study.
  • * History of seizures.
  • * Chronic use of steroids, NSAIDs.
  • * On biologics such as anti-IL6 (omalizumab) and anti-TNF-alpha drugs
  • * Pregnancy or breastfeeding

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Vanderbilt University Medical Center,

Cyndya Shibao, M.D, PRINCIPAL_INVESTIGATOR, Vanderbilt University Medical Center

Study Record Dates

2026-07-01