RECRUITING

Neural Connectivity During Therapy for Adolescent PTSD

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has been slow using current methods. The proposed study uses an innovative approach to identify neural mechanisms of specific phases of trauma-focused therapy for youth with PTSD, allowing a new understanding of brain changes associated with the process of therapy.

Official Title

Neural Connectivity Before and After Each of the Three Treatment Phases of Trauma-focused Therapy for Adolescent Posttraumatic Stress

Quick Facts

Study Start:2022-11-29
Study Completion:2027-02-28
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05423444

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:12 Years to 17 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * ages 12-17 and Tanner stage 2 or above
  2. * history of interpersonal trauma
  3. * PTSD symptoms with a rating of '2' or higher on at least one symptom from each of the 4 clusters, using the Clinician-Administered PTSD Scale for Children and Adolescents, and having a duration of at least one month
  1. * current or past use of psychiatric medications
  2. * severe suicidal/homicidal ideation
  3. * current hospitalization
  4. * other current psychotherapy or previous treatment with TF-CBT
  5. * history of head injury with loss of consciousness for \>5 minutes
  6. * IQ\<85
  7. * major medical illness
  8. * MRI contraindications (metal in body; braces on teeth)
  9. * psychosis, bipolar 1, autism, developmental disorder, panic disorder
  10. * first-degree family member with diagnosis of psychosis or bipolar I disorder
  11. * substance dependence within the past 3 months or current drug use that is frequent

Contacts and Locations

Study Contact

Amy Garrett, PhD
CONTACT
12105678189
garrettas@uthscsa.edu
Natalia Gomez-Giulilani
CONTACT
2105678016
gomezgiulian@uthscsa.edu

Principal Investigator

Amy Garrett, PhD
PRINCIPAL_INVESTIGATOR
University of Texas Health Science Center San Antonio

Study Locations (Sites)

UT Health Department of Psychiatry
San Antonio, Texas, 78229
United States

Collaborators and Investigators

Sponsor: The University of Texas Health Science Center at San Antonio

  • Amy Garrett, PhD, PRINCIPAL_INVESTIGATOR, University of Texas Health Science Center San Antonio

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-11-29
Study Completion Date2027-02-28

Study Record Updates

Study Start Date2022-11-29
Study Completion Date2027-02-28

Terms related to this study

Keywords Provided by Researchers

  • neuroimaging
  • psychotherapy
  • trauma
  • adolescent

Additional Relevant MeSH Terms

  • PTSD
  • Adolescent
  • Psychological Trauma