Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock

Description

A Clinical Events Committee (CEC) will include Cardiac Surgery Professor and chief of cardiac surgery Rose Kelly MD, Professor of Medicine Ganesh Raveendran MD at the University of Minnesota who is the direction of Interventional Cardiology and Professor of Medicine at the University of Minnesota David Benditt. They will review and adjudicate serious and unexpected adverse events independently from the PI and co investigators.

Conditions

Acute Coronary Syndrome, Cardiogenic Shock

Study Overview

Study Details

Study overview

A Clinical Events Committee (CEC) will include Cardiac Surgery Professor and chief of cardiac surgery Rose Kelly MD, Professor of Medicine Ganesh Raveendran MD at the University of Minnesota who is the direction of Interventional Cardiology and Professor of Medicine at the University of Minnesota David Benditt. They will review and adjudicate serious and unexpected adverse events independently from the PI and co investigators.

Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock

Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock

Condition
Acute Coronary Syndrome
Intervention / Treatment

-

Contacts and Locations

Minneapolis

University of Minnesota, Minneapolis, Minnesota, United States, 55455

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-75 years
  • * SCAI D/E CS requiring VA-ECMO support based on treating team's judgement.
  • * MAP \>65 mmHg on \<3 vasopressors/inotropes at the time of consent
  • * Cardiogenic shock due to acute coronary syndrome identified by coronary angiography at the index hospitalization per standard cardiology practice
  • * VA-ECMO for sepsis, pulmonary embolism, COVID-19 related cardiorespiratory failure, severe RV failure due to severe idiopathic pulmonary hypertension
  • * CS due to other (non-ACS) etiologies
  • * Known patient with severe left ventricular dysfunction and stage IV NYHA heart failure being evaluated for or with a history of LVAD and transplantation prior to commencement of VA-ECMO
  • * Profound vasoplegia with MAP \<65 mmHg on 3 vasopressors/inotropes
  • * Moderate to severe aortic regurgitation (contraindication to VA-ECMO)
  • * Moderate to severe aortic stenosis (contraindication to LV instrumentation with PV loop catheter)
  • * Bleeding complications requiring ongoing transfusions of blood products
  • * Ischemic lower extremities
  • * Evidence of circuit thrombosis or fibrin accumulation (turndown increases risk for stroke and clot formation)
  • * Evidence of sepsis or septic shock
  • * Evidence of LV thrombus on echocardiography (contraindication for accessing LV cavity with catheters)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Minnesota,

Demetris Yannopoulous, MD, PRINCIPAL_INVESTIGATOR, University of Minnesota

Study Record Dates

2025-07-01